IP Library › Granted Patent US 12,566,174
Granted Patent B2
US 12,566,174 · App. 16/609,587 · Granted Mar 3, 2026

Method and kit for determining the presence of monosodium urate crystals in joint synovial fluid

Inventors: Srinivas Pentyala (Albany, NY); Lawrence Hurst (Albany, NY)
Assignee: The Research Foundation for The State University of New York
G01N33/5308B01L3/5085G01N1/30B01L2300/043B01L2300/0654G01N2001/302G01N2800/107
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Quick Facts
Patent No.
US 12,566,174
App. No.
16/609,587
Granted
Mar 3, 2026
Kind
B2
Abstract

The present disclosure is directed to a kit and methods for using the same. The kit includes a plate including at least one well, wherein the well includes a silver nitrate and a catalyst. The method includes providing a sample of synovial fluid to a well of a plate, wherein the well includes a silver nitrate and a catalyst and determining a presence of monosodium urate (MSU) crystals, wherein the presence of MSU crystals indicates that gout is detected in the sample.

Claims (20)

1 . A kit configured to detect gout in a sample obtained from a patient comprising:

a plate comprising at least one well, wherein the well contains a silver nitrate, formaldehyde, and alizarin red.

2 . The kit of claim 1 , wherein the silver nitrate and formaldehyde are components of a solution within the at least one well.

3 . The kit of claim 1 , wherein the silver nitrate and formaldehyde are comprised in a film that at least partially coats a surface of the at least one well.

4 . The kit of claim 1 , wherein the silver nitrate is in a range of concentration of about 10% to about 40%.

5 . The kit of claim 1 , wherein the silver nitrate is at a concentration of about 20%.

6 . The kit of claim 1 , wherein the formaldehyde is at a concentration of about 0.002%.

7 . The kit of claim 1 , wherein the kit is configured to attach to a camera.

8 . The kit of claim 7 , wherein the camera comprises a magnification system.

9 . The kit of claim 1 , wherein the well further comprises a solution of about 2% alizarin red.

10 . The kit of claim 1 , wherein the kit further comprises a hinged cover.

11 . The kit of claim 10 , wherein the hinged cover comprises a cover top, wherein the cover top comprises a magnifier.

12 . A method of detecting gout, the method comprising:

providing a sample of synovial fluid to a well of a plate, wherein the well contains a silver nitrate and formaldehyde;

determining a presence of monosodium urate (MSU) crystals, wherein the presence of MSU crystals indicates that gout is detected in the sample.

13 . The method of claim 12 , wherein the time between the providing step and the determining step is about 5 minutes.

14 . The method of claim 12 , wherein the silver nitrate and the formaldehyde are components of a solution within the well.

15 . The method of claim 12 , wherein the silver nitrate and the formaldehyde are comprised in a film that at least partially coats a surface of the well.

16 . The method of claim 12 , wherein the silver nitrate is at a concentration of about 20%.

17 . The method of claim 12 , wherein the formaldehyde is at a concentration of about 0.002%.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2022
From: PENTYALA, SRINIVAS; HURST, LAWRENCE
To: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Reel/Frame 061675/0265 →
Continuity (2)
Provisional Application 62504623 · May 11, 2017
Related Publication 20200150111A1 · May 14, 2020
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