Wound covering for wound monitoring and therapeutic agent delivery

1. A wound covering, comprising:

a flexible main body;

a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a detectable change in appearance in response to a change in a parameter associated with wound exudate, wherein the fibers comprise a plurality of sensor particles and a hydrogel, the sensor particles comprising

one or more indicator compounds configured to undergo the detectable change in appearance in response to the change in the parameter associated with the wound exudate, and

beads comprising an ion-exchange resin or a hydrogel; and

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound.

2. The wound covering of claim 1 , wherein:

the one or more indicator compounds include pH-sensitive dye, glucose-sensitive dye, lactate-sensitive dye, or any combination thereof.

3. The wound covering of claim 2 , wherein:

the sensor element comprises a first region, a second region, a third region, and a fourth region; and

the sensor particles in the fibers of the first region comprise the pH-sensitive dye;

the sensor particles in the fibers of the second region comprise the glucose-sensitive dye;

the sensor particles in the fibers of the third region comprise the lactate-sensitive dye; and

the sensor particles in the fibers of the fourth region are dye-free.

4. The wound covering of claim 1 , wherein the sensor element is incorporated into the main body such that a lower surface of the sensor element forms part of a lower surface of the main body.

5. The wound covering of claim 1 , wherein the therapeutic agent comprises an antibiotic agent, an antifungal agent, a cellular growth-promoting agent, or any combination thereof.

6. The wound covering of claim 1 , further comprising a plurality of particles configured to release oxygen into the wound when the covering is placed on the wound.

7. A method of using the wound covering of claim 1 , the method comprising:

applying the wound covering to a wound; and

detecting the detectable change in appearance of the sensor element.

8. The method of claim 7 , wherein the detecting the detectable change in appearance of the sensor element further comprises:

producing image data of the sensor element, the image data comprising data of a color of the sensor element; and

comparing the data of the color of the sensor element to predetermined color data of the sensor element to determine a value of a parameter associated with exudate from the wound; and

removing the wound covering from the wound if the value of the parameter associated with the exudate from the wound indicates a presence of infection in the wound.

9. A wound covering, comprising:

a flexible main body including at least

a first layer comprising a hydrogel; and

a second layer disposed on the first layer, the second layer comprising a porous hydrophobic material;

a sensor element incorporated into the main body and at least partially incorporated into the first layer, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate; and

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound.

10. The wound covering of claim 9 , wherein:

the wound covering further comprises a third layer disposed on the first layer on an opposite side of the first layer from the second layer such that the first layer is between the third layer and the second layer; and

the third layer is configured to inhibit bacteria growth.

11. The wound covering of claim 9 , wherein the supply of therapeutic agent is incorporated into the hydrogel of the first layer.

12. A wound covering, comprising:

a flexible main body;

a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and

a therapeutic agent delivery element including a mesh formed from a plurality of fibers, the plurality of fibers of the mesh of the therapeutic agent delivery element comprising a hydrogel, wherein

the therapeutic agent is incorporated into the hydrogel.

13. A wound covering, comprising:

a flexible main body;

a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and

a therapeutic agent delivery element including a mesh formed from a plurality of fibers, the plurality of fibers of the mesh of the therapeutic agent delivery element comprising a plurality of porous hydrogel particles, the porous hydrogel particles comprising the therapeutic agent, and

the porous hydrogel particles are configured to release the therapeutic agent when the parameter exceeds a predetermined threshold.

14. The wound covering of claim 13 , wherein the parameter comprises pH of the wound exudate or a temperature of the porous hydrogel particles.

15. The wound covering of claim 14 , wherein the wound covering further comprises a heating element configured to selectively heat the delivery element.

16. A wound covering, comprising:

a flexible main body;

a sensor element incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate;

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound; and

a humidity sensor element incorporated into the main body, the humidity sensor element comprising a substrate having a coating configured to undergo a change in appearance in response to a change in humidity.

17. A wound covering, comprising:

a flexible main body;

a sensor element having a first region, a second region, a third region, and a fourth region incorporated into the main body, the sensor element comprising a mesh formed from a plurality of fibers, the sensor element being configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate,

wherein the fibers comprise a plurality of sensor particles, the sensor particles comprising one or more indicator compounds including pH-sensitive dye, glucose-sensitive dye, lactate-sensitive dye, or any combination thereof, configured to undergo the change in appearance in response to the change in the parameter associated with the wound exudate, and

wherein

the sensor particles in the fibers of the first region comprise the pH-sensitive dye,

the sensor particles in the fibers of the second region comprise the glucose-sensitive dye,

the sensor particles in the fibers of the third region comprise the lactate-sensitive dye, and

the sensor particles in the fibers of the fourth region are dye-free; and

a supply of therapeutic agent configured to diffuse the therapeutic agent from the wound covering into a wound when the wound covering is placed on the wound.