Implantable tissue repair devices
An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.
1. An implantable tissue repair device comprising;
a body comprising a biocompatible hydrogel; and
a plurality of tissue anchoring elements projecting from the body;
wherein the anchoring elements are integrally formed with the body and comprise the same biocompatible hydrogel as the body, and wherein the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue;
wherein the body of the device comprises at least one discrete layer of fibres on top of the anchoring elements and each anchoring element comprises at least one separate discrete layer of fibres located towards a free distal end thereof,
wherein said at least one separate discrete layer of fibres of the anchoring elements comprises a single layer of longitudinal and lateral fibres extending across the full cross-sectional area of the anchoring elements and the hydrogel of the anchoring elements infiltrates spaces between the fibres of the at least one layer of fibres of the anchoring elements, and
wherein the anchoring elements include at least one thread, stitched through the layer of fibres of the anchoring elements and which extends from the layer of fibres of the anchoring elements substantially parallel with a longitudinal axis of the anchoring elements and is stitched to at least one fibre layer of the body.
2. A device as claimed in claim 1 , comprising a front surface and a back surface, and wherein the anchoring elements are located on the back surface, and project therefrom.
3. A device as claimed in claim 1 , wherein the hydrogel comprises at least one material selected from the group consisting of silk fibroin, gelatin, fibrin, fibronectin, alginate, collagen, hyaluronic a acid, chondroitin sulphate, and derivatives thereof.
4. A device as claimed in claim 1 , wherein at least part of the body and/or anchoring elements is porous.
5. A device as claimed in claim 4 , wherein the porous part of the body and/or porous anchoring elements comprises at least 25% or more porosity by volume.
6. A device as claimed in claim 5 , wherein the porous part of the body and/or porous anchoring elements comprises between 65% and 95% porosity by volume.
7. A device as claimed in claim 4 , wherein the porous part of the body and/or anchoring elements comprises an open porous network.
8. A device as claimed in claim 1 , wherein the hydrogel in the body and/or anchoring elements is cross-linked.
9. A device as claimed in claim 8 , wherein the hydrogel is further cross-linked to the fibres of the fibre layer of the body and/or the anchoring elements.
10. A device as claimed in claim 1 , wherein the body and/or anchoring elements comprise at least one porous surface.
11. A device as claimed in claim 10 , wherein the body and/or anchoring elements is porous, and pores of the at least one porous surface communicate with pores within the body and/or anchoring elements.
12. A device as claimed in claim 10 , wherein each porous surface of the at least one porous surface is mineralised.
13. A device as claimed in claim 1 , wherein the anchoring elements have a length of approximately 75%, 65%, 50%, 33% or 25% of a thickness of the body.