Methods and compositions for decreasing concentrations of detrimental proteolytic metabolites, treating health disorders, and/or promoting health benefits in infants or young children
The present invention relates to a nutritional composition comprising at least two human milk oligosaccharides, for use to decrease the concentration of detrimental proteolytic metabolites (e.g. branched short chain fatty acids) in the digestive tract in an infant or a young child.
1. A method of decreasing a concentration of detrimental proteolytic metabolites comprising a branched short chain fatty acid (SCFA) selected from the group consisting of isobutyrate, isovalerate, 2-methyl butyrate, and combinations thereof in a digestive tract in an infant or a young child in need thereof by at least 5% in comparison to a production in the digestive tract obtained with another nutritional composition comprising no human milk oligosaccharides, the method comprising administering to the infant or young child a nutritional composition comprising at least two human milk oligosaccharides in a total amount of from 0.1 to 10 wt % of the nutritional composition and a hydrolyzed protein, the at least two human milk oligosaccharides comprising at least 2′-fucosyllactose (2′FL) and lacto-N-neotetraose (LNnT).
2. The method according to claim 1 , wherein the at least two human milk oligosaccharides further comprise sialylated oligosaccharides.
3. The method according to claim 1 , wherein the nutritional composition further comprises a fucosylated oligosaccharide selected from the group consisting of 3′ fucosyllactose, difucosyllactose, lacto-N-fucopentaose I, lacto-N-fucopentaose II, lacto-N-fucopentaose III, lacto-N-fucopentaose V, lacto-N-fucohexaose, lacto-N-difucohexaose I, fucosyllacto-N-hexaose, fucosyllacto-N-neohexaose I, fucosyllacto-N-neohexaose II, difucosyllacto-N-hexaose I, difucosyllacto-N-neohexaose I, difucosyllacto-N-neohexaose II, fucosyl-para-Lacto-N-hexaose, and combinations thereof.
4. The method according to claim 3 , wherein the fucosylated oligosaccharide comprises difucosyllactose (DFL or DiFL).
5. The method according to claim 1 , wherein the nutritional composition further comprises lacto-N-tetraose (LNT).
6. The method according to claim 1 , wherein the nutritional composition comprises a sialylated oligosaccharide selected from the group consisting of 3′ sialyllactose (3SL), 6′ sialyllactose (6SL) and combinations thereof.
7. The method according to claim 1 , wherein the at least two human milk oligosaccharides further comprise one human milk oligosaccharide selected from the group consisting of DFL, LNT, 3SL, 6SL, and combinations thereof.
8. The method according to claim 1 , wherein the nutritional composition comprises at least six human milk oligosaccharides 2′FL, DFL, LNnT, LNT, 3SL and 6SL.
9. The method according to claim 1 , wherein the concentration of detrimental proteolytic metabolites in the digestive tract is decreased with the diversity of the at least two human milk oligosaccharides present in the nutritional composition.
10. The method according to claim 1 , wherein the at least two human milk oligosaccharides are present in a total amount of from 0.5 to 7 wt % of the nutritional composition.
11. The method according to claim 1 , wherein the nutritional composition is in a form selected from the group consisting of an infant formula, a starter infant formula, a follow-on or follow-up infant formula, a baby food, an infant cereal composition, a fortifier and a supplement.
12. A method of treating or reducing a risk of allergies by decreasing a concentration of detrimental proteolytic metabolites comprising a branched short chain fatty acid (SCFA) selected from the group consisting of isobutyrate, isovalerate, 2-methyl butyrate, and combinations thereof in an infant or young child in need thereof by at least 5% in comparison to a production in the digestive tract obtained with another nutritional composition comprising no human milk oligosaccharides, the method comprising administering to the infant or young child a nutritional composition comprising at least two human milk oligosaccharides in a total amount of from 0.1 to 10 wt % of the nutritional composition and a hydrolyzed protein, the at least two human milk oligosaccharides comprising at least 2′FL and LNnT.
13. The method of claim 1 , wherein the nutritional composition is a growing-up milk.
14. The method of claim 1 , wherein the infant or young child was born by C-section.