Compound and pharmaceutical composition containing the same

1. A compound of formula (I):

or a pharmaceutically acceptable salt thereof,

wherein

Z 1 is N or C—R 2 ;

Z 2 1is C or N;

Z 3 is N or C—X—R 1, with the proviso that no more than two of Z 1 , Z 2 and Z 3 are N;

X is a direct bond, —(CH 2 ) n —, —O—, —NR a —, —(C═O)NH—or —(C═O)—, in which n is 1, 2 or 3, and R a is hydrogen or alkyl;

Y is —CH—, —NR b —, O or S, in which R b is hydrogen or alkyl;

L is a direct bond, —(CH 2 ) m —or —NH—, in which m is 1, 2 or 3;

R 1 is hydrogen, halogen, cyano, alkyl, alkyloxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein each of alkyloxy, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted with one to three moieties selected from the group consisting of halogen, hydroxyl, nitro, cyano, —NR c R d , lower alkyl carbamoyl, heterocycloalkyl, alkyl optionally substituted with one to three halo or aryl, and alkyloxy optionally substituted with one to three halo, alkyloxy, cycloalkyl, heterocycloalkyl, —NR e R f or aryl, in which each of R c , R d , R e and R f independently is hydrogen or alkyl;

R 2 is hydrogen, halogen, alkyl, alkyloxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, wherein each of alkyloxy, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted with one to three moieties selected from the group consisting of halogen, hydroxyl, nitro, cyano, —NR g R h , lower alkyl carbamoyl, alkynyl, alkyl optionally substituted with one to three halo, and alkyloxy optionally substituted with one to three halo or alkyloxy, in which each of R g and R h independently is hydrogen or alkyl;

R 3 is

in which M is O or S; and

R 4 is H or alkyl,

wherein X is O when R 3 is

and M is O;

wherein —X—R, is not hydrogen when R 3 is

and M is S; and

wherein

and —X—R 1 is not hydrogen when R 3 is

2. The compound or salt of claim 1 , wherein

3. The compound or salt of claim 1 , wherein

4. The compound or salt of claim 3 , wherein X is a direct bond.

5. The compound or salt of claim 3 , wherein L is a —CH 2 —, and R 3 is

6. The compound or salt of claim 3 , wherein R 1 is aryl or heteroaryl, wherein each of aryl and heteroaryl is optionally substituted with one to three moieties selected from the group consisting of halogen, hydroxyl, nitro, cyano, —NR c R d , lower alkyl carbamoyl, heterocycloalkyl, alkyl optionally substituted with one to three halo or aryl, and alkyloxy optionally substituted with one to three halo, alkyloxy, cycloalkyl, heterocycloalkyl, —NR e R f or aryl, in which each of R c , R d , R e and R f independently is hydrogen, methyl or ethyl.

7. The compound or salt of claim 6 , wherein Ri is phenyl or pyridinyl, wherein each of phenyl or pyridinyl is optionally substituted with one to three alkyloxy optionally substituted with one to three halo, alkyloxy, cycloalkyl, heterocycloalkyl, —NR e R f or aryl, in which each of R c , R d , R e and R f independently is hydrogen, methyl or ethyl.

8. The compound or salt of claim 3 , wherein R 4 is H or methyl.

9. The compound or salt of claim 4 , wherein L is a —CH 2 —; R 3 is

R 4 is H or methyl; and R 1 is phenyl or pyridinyl, wherein each of phenyl or pyridinyl is optionally substituted with one or two ethoxy, butoxy, methoxy substituted with ethoxy, or ethoxy substituted with dimethylamino.

10. The compound or salt of claim 1 , wherein

11. The compound or salt of claim 10 , wherein Xis a direct bond, —CH 2 —, —O—, —N(CH 3 )—, —(C═O)NH—or —(C═O)—.

12. The compound or salt of claim 10 , wherein L is a direct bond, and R 3 is

in which M is O or S.

13. The compound or salt of claim 10 , wherein L is a —CH 2 —, and R 3 is

14. The compound or salt of claim 10 , wherein R 1 is hydrogen, halogen, cyano, alkoxy, aryl or heteroaryl, wherein each of aryl and heteroaryl is optionally substituted with one to three moieties selected from the group consisting of halogen, hydroxyl, nitro, cyano, —NR c R d , lower alkyl carbamoyl, heterocycloalkyl, alkyl optionally substituted with one to three halo or aryl, and alkyloxy optionally substituted with one to three halo, alkyloxy, cycloalkyl, heterocycloalkyl, —NR e R f or aryl, in which each of R c , R d , R e and R f independently is hydrogen, methyl or ethyl.

15. The compound or salt of claim 14 , wherein R 1 is phenyl, which is optionally substituted with one to three moieties selected from the group consisting of halogen and alkyl optionally substituted with one to three halo.

16. The compound or salt of claim 10 , wherein R 2 is aryl or heteroaryl, wherein each of aryl and heteroaryl is optionally substituted with one to three moieties selected from the group consisting of halogen, nitro, cyano, lower alkyl carbamoyl, alkynyl, alkyl optionally substituted with one to three halo, and alkyloxy optionally substituted with one to three halo or alkyloxy.

17. The compound or salt of claim 16 , wherein R 2 is phenyl, which is optionally substituted with one to three moieties selected from the group consisting of halogen, alkyl optionally substituted with one to three halo, and alkyloxy.

18. The compound or salt of claim 10 , wherein R 4 is H or methyl.

19. The compound or salt of claim 10 , wherein X is —O—; Lisa direct bond; R 3 is

in which M is S; R 4 is H; R 1 is phenyl optionally substituted with fluoro, tert-pentyl or trifluoromethyl; and R 2 is phenyl substituted with ethoxy, butoxy, fluoro, tert-butyl, tert-pentyl or trifluoromethyl.

20. The compound or salt of claim 10 , wherein Xis a direct bond; L is a direct bond; R 3 is

in which M is S; R 4 is H; R 1 is phenyl optionally substituted with one or two fluoro; and R 2 is phenyl substituted with tert-butyl or tert-pentyl.

21. The compound or salt of claim 1 , which is any one selected from the group consisting of 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(3-ethoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-ethoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-hydroxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-nitrophenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-(dimethylamino)phenyl)-1,3,4-thiadiazol-2-y1)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-propoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-(trifluoromethoxy)phenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-iodophenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-bromo-3-nitrophenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-isopropoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-isopropoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl) -N-(5 -(4-(pentan-3 -yl oxy)phenyl)- 1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-propoxyphenyl)- 1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(2,4-diethoxyphenyl)- 1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-hydroxyphenyl)- 1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-butoxyphenyl)- 1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-butoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(2-(pentan-3 -yloxy) phenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(2-butoxy-4-ethoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2, 4,6-triethoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(3 -ethoxypyridin-4-yl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-ethoxy-2-(ethoxymethoxy)phenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-ethoxy-2-(2-(4-methylpiperazin- 1-yl) ethoxy)phenyl)- 1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(2(3-(dimethylamino) propoxy)-4-ethoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-(2-(dimethylamino) ethoxy)-4-ethoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(5 -ethoxypyridin-2-yl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(3-(2-(dimethylamino)ethoxy)pyridin-4-yl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-ethoxy-2-(2-methoxyethoxy) phenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl) -N-(5 -(4-propylphenyl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl) -N-(5 -(4-ethoxypyridin-3 -yl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4, 6-diethoxypyridin-3 -yl)-1,3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2,4-diethoxyphenyl)-1,3,4-thiadiazol-2-yl) -N-methylacetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4,6-diethoxypyridin-3 -yl)- 1,3 ,4-thiadiazol-2-yl) -N-methylacetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5 -(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-propoxyphenyl)-1,3,4-oxadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(2-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(3-nitrophenyl)-4-(p-tolyl)thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(4-(4-bromophenyl)-5-phenylthiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-bromophenyl)-4-(p-tolyl)thiazol- 2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-fluorophenyl)-4-(p-tolyl) thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(3,4-dimethoxyphenyl) -4-(p-tolyl)thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl) -N-(5-(4-fluorophenyl)-4-(4-propoxyphenyl)thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(3,5-bis(trifluoromethyl)phenyl)-4-(p-tolyl)thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-bromo-4-(3-methoxyphenyl)thiazol-2-yl) acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(4-(4-ethoxyphenyl)-5-(4-fluorophenyl) thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(4,5-bis(4-bromophenyl) thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-ethoxyphenyl) thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(4-(2,4-diethoxyphenyl) thiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(4-(4-ethoxyphenyl) -5-phenoxythiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-benzyl-4-(4-ethoxyphenyl)thiazol-2-yl)acetamide, 1-(2-aminobenzo[d]thiazol-6-yl)-3-(5-(4-ethoxyphenyl)-1, 3,4-thiadiazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-ethoxyphenyl) thiophen-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl)-N-(5-(4-ethoxy-2-(2-methoxyethoxy)phenyl)-1H-imidazol-2-yl)acetamide, 2-(2-aminobenzo[d]thiazol-6-yl) -N-(5-(2,4-diethoxyphenyl)-1H-imidazol-2-yl)acetamide, N-(4-(4-bromophenyl)-5-phenoxythiazol-2-yl) -5-nitrothiophene-2-carboxamide, N-(4-(4-bromophenyl)-5-(4-(trifluoromethoxy)phenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(3-nitrophenyl) -5-phenoxythiazol-2-yl)thiophene-2-carboxamide, N-(4-(3-methoxyphenyl) -5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(2-ethoxyphenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl) -5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-bromophenyl) -5-(4-(trifluoromethyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl)-5-(4-(trifluoromethoxy)phenoxy)thiazol-2-yl) thiophene-2-carboxamide, 5-nitro-N-(5-phenoxy-4-(4-propoxyphenyl)thiazol-2-yl) thiophene-2-carboxamide, N-(4-(4-isopropoxyphenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene -2-carboxamide, N-(4-(4-bromophenyl)-5-(3-(trifluoromethyl) phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(2,4-diethoxyphenyl) -5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl) -5-(pyridin-3-yloxy)thiazol-2-yl)thiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(2-methoxyethoxy) phenyl)-5-(pyridin-3-yloxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(2-methoxyethoxy)phenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene -2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl)-5-(3-(trifluoromethyl) phenoxy)thiazol-2-yl)thiophene-2-carboxamide, N-(4-(4-bromophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-(4-fluorophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2-ethoxyphenoxy)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(3-fluorophenoxy)thiazol-2-yl) -5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(3-(trifluoromethyl) phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(3-fluorophenoxy) -4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl) -5-(4-(trifluoromethyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl)-5-(4-(trifluoromethyl)phenoxy)thiazol-2-yl) thiophene-2-carboxamide, N-(5-(4-bromophenoxy)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromo-3,5-dimethylphenoxy)-4-(4-propoxyphenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-(tert-butyl) phenoxy)-4-(4-ethoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenoxy) -4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-fluorophenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-fluorophenyl)-5-(2-(trifluoromethoxy)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-fluorophenyl)-5-(4-(trifluoromethoxy) phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-methoxyphenyl) -5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenoxy)-4-(4-(methylcarbamoyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(3,5-diethoxyphenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2,4-difluorophenoxy)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2-chloro-4-(trifluoromethyl)phenoxy)-4-(4-propoxyphenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-cyanophenoxy)-4-(4-propoxyphenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-cyano-2-methoxyphenoxy) -4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(5-(3,3-dimethylbut-l-yn-l-yl)thiophen-2-yl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(5-bromothiophen-2-yl)-5-phenoxythiazol-2-yl)-5-nitrothiophene -2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl)-5-(pyridin-4-yloxy) thiazol-2-yl)thiophene-2-carboxamide, N-(5-(3,4-dichlorophenoxy)-4-(4-propoxyphenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2-chloro-4-fluorophenoxy) -4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(5-(3 -(dimethylamino)prop-1-yn-l-yl)thiophen-2-yl)-5-phenoxythiazol-2-yl)-5-nitrothiophene -2-carboxamide, N-(4-(4-ethoxyphenyl)-5-phenoxythiazol-2-yl)-5-nitrofuran -2-carboxamide, 5-nitro-N-(5-phenoxy-4-(4-propoxyphenyl)thiazol-2-yl)furan-2-carboxamide, N-(5-(4-fluorophenoxy)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrofuran-2-carboxamide, N-(5-(3,5-difluorophenoxy)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(6-ethoxypyri din-3 -yl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-propoxyphenyl)-5-(quinolin-8-yloxy) thiazol-2-yl)thiophene-2-carboxamide, N-(4-(4-ethoxy-2-fluorophenyl)-5-phenoxythiazol-2-yl) -5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(3-fluorophenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(4-fluorophenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(2-fluorophenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2-fluorophenoxy)-4-(4-propoxyphenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-(tert-pentyl)phenyl) -5-phenoxythiazol-2-yl)thiophene-2-carboxamide, 5-nitro-N-(4-(4-nitrophenyl) -5-phenoxythiazol-2-yl)thiophene-2-carboxamide, 5-nitro-N-(5 -phenoxy-4-(3, 4,5-trimethoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide, N-(4-(4-fluorophenyl)-5-(4-(tert-pentyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenoxy) -4-(4-(tert-pentyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-(tert-butyl)phenoxy)-4-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-butylphenoxy)-4-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-butoxyphenoxy)-4-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(hexyloxy)phenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(5-(4-(tert-pentyl)phenoxy)-4-(4-(trifluoromethyl)phenyl)thiazol-2-yl) thiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(2-fluorophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(4-fluorophenoxy)thiazol-2-yl) -5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-(trifluoromethyl) phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(4-(4-(pentyloxy)phenyl)-5-phenoxythiazol-2-yl)thiophene-2-carboxamide, 5-nitro-N-(5-phenoxy-4-(4-propylphenyl)thiazol-2-yl)thiophene-2-carboxamide, N-(5-(2-fluorophenoxy)-4-(4-propylphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butylphenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butylphenyl)-5-(2-fluorophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(5-phenoxy-4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)thiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-phenoxythiazol-2-yl)-N-methyl-5-nitrothiophene-2-carboxamide, N-(5-(2-fluorophenoxy)-4-(4-(trifluoromethyl) phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(5-phenoxy -4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)thiophene-2-carboxamide, N-(5-(2-fluorophenoxy)-4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromophenoxy)-4-(4-butoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromo-3,5-dimethylphenoxy)-4-(4-butoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-propylphenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-(4-butylphenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl) -5-(4-(tert-butyl)phenoxy)thi azol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(4-cyanophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-((5-aminopentyl)oxy)phenyl)-5-phenoxythiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(4-propylphenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butylphenyl)-5-(4-fluorophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-propoxyphenoxy) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-(tert-butyl) phenoxy)-4-(4-(tert-butyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(4-(tert-pentyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromo-3,5-dimethylphenoxy)-4-(4-(tert-butyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromo-3,5-dimethylphenoxy)-4-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-(tert-pentyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-(tert-butyl)phenoxy)-4-(4-ethylphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethylphenyl)-5-(4-(tert-pentyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butylphenyl)-5-(4-(tert-pentyl)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(p-tolyloxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(3,5-dimethylphenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-(dimethylamino)phenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-morpholinophenoxy)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromophenyl)-4-(p-tolyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, 5-nitro-N-(5-(3-nitrophenyl)-4-(p-tolyl)thiazol-2-yl)thiophene-2-carboxamide, N-(5-(3,4-dimethoxyphenyl)-4-(p-tolyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(3,5-bis(trifluoromethyl)phenyl)-4-(p-tolyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenyl)-4-(p-tolypthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-bromophenyl)-5-phenylthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-bromo-4-(4-bromophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-bromo-4-(2-nitrophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-bromo-4-(3-nitrophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-bromo-4-(3-methoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenyl)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-bromo-4-(4-ethoxyphenyl)thiazol -2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-butoxyphenyl)-5-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(4-(trifluoromethyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromo-3-ethoxyphenyl)-4-(p-tolypthiazol -2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-phenylthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5 -(4-methylpiperazin-1-yl)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, ethyl2-(5 -nitrothiophene-2-carboxamide)-4-(4-propoxyphenyl)thiazole-5-carboxylate, N-(4-(4-(tert-butyl)phenyl)-5-(4-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(3,5-difluorophenyl)-4-(4-ethoxyphenyl)-2-(5-nitrothiophene-2-carboxamido)thiazole-5 -carboxamide, N-(4-(4-ethoxyphenyl)-5 -(methyl(phenyl)amino)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(morpholine-4-carbonyl)-4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-methylpiperazine-1-carbonyl)4-(4-propoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(2,4-difluorophenyl)-2-(5-nitrothiophene-2-carboxamido)-4-(4-propoxyphenyl)thiazole-5-carboxamide, N-(5-benzyl-4-(4-ethoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(4-fluorobenzypthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-ethoxyphenyl)-5-(3-fluorobenzypthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-fluorobenzypthiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(3,5-difluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5 -(2,4-difluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-fluorophenyl)-4-(4-(tert-pentyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(3-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, ethyl, 4-(4-(tert-butyl)phenyl)-2-(5-nitrothiophene-2-carboxamido)thiazole-5-carboxylate, N-(4-(4-(tert-butyl)phenyl)-5-(4-methylpiperazine-l-carbonyl)thiazol-2-yl) -5-nitrothiophene-2-carboxamide, 4-(4-(tert-butyl)phenyl)-N-cyclopropyl-2-(5-nitrothiophene -2-carboxamido)thiazole-5-carboxamide, ethyl 4-(4-ethoxyphenyl)-2-(5-nitrothiophene- 2-carboxamido)thiazole-5-carboxylate, N-(4-(4-(tert-butyl)phenyl)-5-(3,4-difluorophenyl) thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2,4-difluorophenyl)-4-(4-(tert-pentyl)phenyl)thiazol-2-yl)-5 -nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-(2-fluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl) phenyl)-5-(morpholine-4-carbonyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-cyanothiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(3,4,5-trifluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(2,4,6-trifluorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(4-bromophenyl)-4-(4-(tert-butyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-methoxyphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(2-chlorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(3-chlorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(5-(2-bromophenyl)-4-(4-(tert-butyl)phenyl)thiazol -2-yl)-5-nitrothiophene-2-carboxamide, N-(5 -(3 -bromophenyl)-4-(4-(tert-butyl)phenyl)thiazol -2-yl)-5-nitrothiophene-2-carboxamide, N-(4-(4-(tert-butyl)phenyl)-5-(4-chlorophenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, and N-(5-bromo-4-(4-(tert-butyl)phenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide, N-(3 -(4-bromophenyl)-1H-pyrazol-5-yl)-5-nitrothiophene-2-carboxamide.

22. A pharmaceutical composition comprising a compound or salt of claim 1 and a pharmaceutically acceptable carrier.

23. A method for treating a cancer, comprising: administering to a subject in need thereof an effective amount of a compound or salt of claim 1 , wherein the cancer is selected from the group consisting of pancreatic cancer, renal cell carcinoma, breast cancer, colon cancer, colorectal cancer, lung cancer and liver cancer.