Nanoparticle, contrast agent for magnetic resonance imaging containing same, and ligand compound
Provided is a novel nanoparticle, a contrast agent for magnetic resonance imaging containing the same, and a ligand compound used for production of the nanoparticle. The present invention relates to a nanoparticle including: a metal particle containing iron oxide; and a ligand which is bound to a metal atom on a surface of the metal particle and is represented by formula (3): where m is an integer of 1 to 4, and a broken line represents a coordinate bond with a metal atom on the surface of the metal particle.
1. A nanoparticle, comprising:
a metal particle containing iron oxide; and
a ligand which is bound to a metal atom on a surface of the metal particle and is represented by formula (3):
where m is an integer of 1 to 4, and a broken line represents a coordinate bond with a metal atom on the surface of the metal particle.
2. The nanoparticle as set forth in claim 1 , wherein the ligand bound to the metal atom on the surface of the metal particle is a ligand represented by formula (1):
where a broken line represents a coordinate bond with the metal atom on the surface of the metal particle.
3. The nanoparticle as set forth in claim 1 , wherein m is 1, 2, or 4 in the formula (3).
4. The nanoparticle as set forth in claim 1 , wherein the metal particle containing the iron oxide is an iron oxide particle.
5. The nanoparticle as set forth in claim 1 , wherein the metal particle has an average particle diameter of 5 nm or less.
6. The nanoparticle as set forth in claim 5 , wherein the metal particle has an average particle diameter of 4 nm or less.
7. The nanoparticle as set forth in claim 5 , wherein the metal particle has an average particle diameter of 3 nm or less.
8. A contrast agent for magnetic resonance imaging, comprising a nanoparticle recited in claim 1 .
9. The contrast agent as set forth in claim 8 , wherein the contrast agent is a positive contrast agent.