FXR agonist
The present invention belongs to the technical field of pharmaceuticals, and particularly relates to a compound of formula (I), a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester, wherein R 1 , X 1 , X 2 , M, Ar, ring A, ring B and L are as defined in the specification. The present invention also relates to: a preparation method for the compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester; a pharmaceutical composition and pharmaceutical formulation containing the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer of the compound, the salt or the ester; and a use of the compound, the pharmaceutically acceptable salt, the ester or the stereoisomer of the compound, the salt or the ester in the preparation of a medicament for treating and/or preventing FXR-mediated diseases.
1. A compound of general formula (II) a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer:
wherein Q 1 hydrogen;
R 1 is cyclopropyl;
X 1 and X 2 both are O;
Ar is phenyl optionally substituted by 1 to 2 Q 2 ; and each Q 2 is independently selected from chlorine and methoxy.
2. A compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester, wherein the compound is selected from:
3. A compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester thereof, wherein the compound is
4. A pharmaceutical formulation containing the compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester of claim 1 , wherein the pharmaceutical formulation contains one or more pharmaceutically acceptable carriers and/or diluents, and can be of any pharmaceutically acceptable dosage form.
5. A method for treating an FXR-mediated disease and related disease in a subject, wherein the method comprises administering to a subject in need thereof a therapeutically effective amount of the compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester of claim 1 or a pharmaceutical composition containing the compound, a pharmaceutically acceptable salt thereof, an ester thereof, or a stereoisomer of the compound, the salt or the ester of claim 1 ;
wherein the disease is selected from primary sclerosing cholangitis, fatty liver, cirrhosis, cholestasis, alcoholic steatohepatitis, primary biliary cirrhosis and nonalcoholic steatohepatitis.
6. The method of claim 5 , wherein the diseases are selected from alcoholic fatty liver disease and nonalcoholic fatty liver disease.