Topical compositions
The present invention relates to topical compositions comprising erythrulose and hydroxyacetophenone as well as the use thereof for the prevention and/or treatment of ailments associated with Malassezia yeast, Propionibacterium acnes as well as the protection against molds such as in particular Aspergillus brasiliensis.
1. A topical composition comprising erythrulose and from 0.01 wt. % to 2 wt. %, based total weight of the composition, of hydroxyacetophenone.
2. The topical composition according to claim 1 , wherein the erythrulose is present in an amount from 0.005 to 5 wt. %, based on the total weight of the composition.
3. The topical composition according to claim 1 , wherein the hydroxyacetophenone is p-hydroxyacetophenone.
4. The topical composition according to claim 1 , wherein the composition is a cosmetic or pharmaceutical composition.
5. The topical composition according to claim 4 , wherein the composition is a shampoo preparation, a hair conditioner, an oil-in-water (O/W) emulsion, a water-in-oil (W/O) emulsion or a gel.
6. The topical composition according to claim 1 , wherein the composition further comprises water and at least one agent selected from the group consisting of surfactants, emulsifiers, thickeners and oils.
7. The topical composition according to claim 1 , wherein the hydroxyacetophenone is present in an amount from 0.1 wt. % to 1 wt. %, based on the total weight of the composition.
8. The topical composition according to claim 1 , wherein the hydroxyacetophenone is present in an amount from 0.1 wt. % to 0.6 wt. %, based on the total weight of the composition.
9. The topical composition according to claim 1 , wherein the erythrulose is present in an amount from 0.01 to 3 wt. %, based on the total weight of the composition.
10. The topical composition according to claim 1 , wherein the erythrulose is selected is present in an amount from 0.025 to 2 wt. %, based on the total weight of the composition.
11. A method of treating skin and/or scalp which comprises contacting the skin and/or scalp with the topical composition according to claim 1 .
12. The method according to claim 11 , wherein the method is for the treatment, prevention and/or prophylaxis of itching skin and/or for maintaining a healthy skin homeostasis and/or for maintaining skin microbiome balance.
13. A method for the treatment of itching skin and/or for maintaining a healthy skin homeostasis and/or for maintaining skin microbiome balance, wherein the method comprises topically applying to skin an effective amount of the topical composition according to claim 1 .
14. The method according to claim 13 , wherein the method is for the treatment, prevention and/or prophylaxis of Malassezia yeast.
15. The method according to claim 14 , wherein the Malassezia yeast comprises Malassezia furfur.
16. The method according to claim 15 , wherein the diseases and/or disorders are selected from the group consisting of pityriasis versicolor , dandruff formation, seborrheic dermatitis, atopic dermatitis and psoriasis.
17. A method for the prevention and/or prophylaxis of acne, wherein the method comprises topically applying to skin an amount of the topical composition according to claim 1 sufficient to provide prevention and/or prophylaxis of acne.