Peptide and small molecule agonists of EphA and their uses
A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of a compound, the small molecule having a general formula: A-L-X—Z (I).
1. A pharmaceutical composition comprising:
a compound having the formula:
wherein R 2 is selected from H, an alkoxy or a C 1-6 alkyl group,
Z is selected from the group consisting of
R 7 is selected from H, an alkoxy or a C 1-6 alkyl group, and n 1 is an integer from 1-20, and pharmaceutically acceptable salts thereof; and
a pharmaceutically acceptable carrier.
2. The pharmaceutical composition of claim 1 , the compound selected from the group consisting of:
pharmaceutically acceptable salts thereof.
3. The pharmaceutical composition of claim 2 , the compound having the formula:
or a pharmaceutically acceptable salt thereof.
4. The pharmaceutical composition of claim 2 , the compound having the formula:
or a pharmaceutically acceptable salt thereof.
5. The pharmaceutical composition of claim 1 , the compound selected from the group consisting of:
pharmaceutically acceptable salts thereof.
6. The pharmaceutical composition of claim 1 , the compound selected from the group consisting of:
pharmaceutically acceptable salts thereof.