IP Library › Granted Patent US 11,426,368
Granted Patent B2
US 11,426,368 · App. 16/631,066 · Granted Aug 30, 2022

Plasminogen activator inhibitor-1 (PAI-1) inhibitor and method of use

Inventors: Daniel A. Lawrence (Ann Arbor, MI); Cory Emal (Ann Arbor, MI); Ashley Reinke (Ann Arbor, MI); Shih-Hon Li (Ypsilanti, MI)
Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY
A61K31/137
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Quick Facts
Patent No.
US 11,426,368
App. No.
16/631,066
Granted
Aug 30, 2022
Kind
B2
Abstract

Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.

Claims (2)

1. A compound having a structure of:

or a pharmaceutically acceptable salt thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2020
From: EMAL, CORY
To: EASTERN MICHIGAN UNIVERSITY
Reel/Frame 051637/0497 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2020
From: LAWRENCE, DANIEL A.; REINKE, ASHLEY; LI, SHIH-HON
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 051637/0570 →
Continuity (2)
Provisional Application 62537513 · Jul 27, 2017
Related Publication 20200147007A1 · May 14, 2020
Cited By (1)
US 12,390,427