Inhibitors of RORγ
The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.
1. A method of converting crystalline Forms E, F, and G of a bis-hydrogen bromide salt having the following structural formula:
to crystalline Form D bis-hydrogen bromide salt comprising:
i) slurrying a composition comprising one or more of crystalline Forms E, F, and G in a mixture of isopropyl acetate/water; and
ii) separating the crystalline form D bis-hydrogen bromide salt from the mixture of isopropyl acetate/water.
2. The method of claim 1 , wherein the composition is slurried in a mixture of isopropyl acetate comprising 0.25% to 2.5% v/v of water.
3. The method of claim 1 , wherein the separation is done by filtration.
4. The method of claim 1 , wherein the amount of the one or more crystalline Forms E, F, and G present in the composition is greater than 90% by weight.
5. The method of claim 1 , wherein the bis-hydrogen bromide salt is of crystalline Form D characterized by at least three x-ray powder diffraction peaks at 2Θ angles selected from 14.24°, 15.24°, 15.90°, 18.54°, 18.82°, and 22.46°.
6. The method of claim 1 , wherein the bis-hydrogen bromide salt is of crystalline Form D characterized by at least three x-ray powder diffraction peaks at 2Θ angles selected from 14.24°, 15.24°, 15.90°, 18.54°, 18.82°, and 22.46°.