Topical herbal compositions
View Patent ↗The present invention provides topical formulations having an autophagy stimulating and/or heme oxygenase and activating/triggering effect on human skin for cosmetic and pharmaceutical use. Furthermore, the present invention provides topical formulations that trigger production of VEGF-C, reduce melanin synthesis and boost energy and cell function. Moreover, the present invention provides a new process for producing a herbal composition comprising a mixture of components of Bellis perennis L . and optionally Hieracium pilosella by aqueous extraction and the herbal composition comprising a mixture of components produced by the process of the present invention. The pharmaceutical formulations according to the present invention may be used for the treatment or prevention of dark circles under the eye and/or puffy eyes. The herbal composition according to the present invention may also be used in a cosmetic formulation for the cosmetic treatment or prevention of dark circles under the eye and/or puffy eyes.
1. An herbal composition comprising a mixture of a) components obtained from Bellis perennis by a solvent extraction or a pressed juice process and b) components obtained from Hieracium pilosella by a solvent extraction or a pressed juice process, wherein the a) components and the b) components are present in the mixture in a ratio of 1:1 to 3:1 (w:w), and wherein the mixture of a) components and b) components is present in an amount effective for treatment or reduction of formation of dark circles to an eye area of a person in need of the treatment or reduction of formation of dark circles to an eye area, wherein the dark circles are not caused by excess epidural pigmentation of the skin.
2. The herbal composition according to claim 1 , having a pH-value of between about pH 3 to 7.5.
3. The herbal composition according to claim 1 , wherein the mixtures of a) components and b) components are alcoholic, glycolic or aqueous extracts.
4. The herbal composition according to claim 1 , wherein the mixtures of a) components and b) components are press juices.
5. The herbal composition according to claim 1 , wherein the mixture of a) components and b) components are obtained from a mixture of the starting plants.
6. The herbal composition according to claim 1 , wherein at least one of the a) components, the b) components, or the mixture of a) components and b) components have been subjected to fermentation.
7. The herbal composition according claim 6 , wherein said fermentation is Lactobacillus, Bifidobacter or Lactococcus fermentation.
8. The herbal composition according to claim 1 , wherein the composition is formulated for topical application.
9. The herbal composition according to claim 8 , wherein the composition is formulated as a cream, an ointment, an emulsion, a tonic, stick, dispersion, a formulation comprising a surfactant cleanser, a solution, a micellar water, a gel, a mask, a moist tissue pad or moist tissue mask.
10. The herbal composition according to claim 1 , wherein the composition comprises 1 to 10% (w/w) of the mixture of a) components and b) components.
11. The herbal composition according to claim 1 , wherein the composition comprises 1 to 50% (w/w) of the mixture of a) components and b) components.
12. The herbal composition according to claim 1 , wherein the components are obtained from each of the Bellis perennis and Hieracium pilosella plants separately and then combined.
13. The herbal composition according to claim 1 , wherein the composition has a pH-value of from about pH 4.0 to 6.5.
14. The herbal composition according to claim 1 , wherein the composition comprises 10 to 30% (w/w) of the mixture of a) components and b) components.
15. The herbal composition according to claim 1 , wherein the composition is formulated as a pharmaceutical formulation.
16. The herbal composition according to claim 1 , wherein the composition is formulated as a cosmetic formulation.
17. A method of treatment or reduction of formation of dark circles under the eyes and/or puffy eyes/puffiness comprising application of the herbal composition of claim 5 to an eye area of a person in an amount effective to treat or reduce formation of dark circles under the eyes and/or puffy eyes/puffiness, wherein the dark circles are not caused by excess epidural pigmentation of the skin.
18. The method according to claim 17 , wherein the dark circles under the eyes and/or puffiness are caused by any one of heredity, allergies, sleep deprivation/fatigue, oversleeping, eczema, contact dermatitis, hay fever/allergic rhinitis, stress, thinning skin and/or loss of fat and collagen with age, iron deficiency, minor trauma, crying, life style choices, fluid retention, excessive exposure to the sun, rubbing and scratching of eyes and medication.
19. The method according to claim 17 , wherein the dark circles under the eyes and/or puffiness are caused by any one of thinning skin and/or loss of fat and collagen with age, life style choices, fluid retention, and influence of circadian rhythm by life style and life conditions.
20. The method according to claim 17 , wherein the method comprises reduction of periorbital dark circles and/or periorbital edema, and wherein the herbal composition used in the method acts as an autophagy stimulator, heme oxygenase activator or VEGF-C production trigger.