IP Library › Granted Patent US 11,434,218
Granted Patent B2
US 11,434,218 · App. 16/634,915 · Granted Sep 6, 2022

Polyphenol production method

Inventors: Erika Takahashi (Tokyo, JP); Yoshie Fujimori (Tokyo, JP); Youhei Jikihara (Tokyo, JP); Tsuruo Nakayama (Tokyo, JP)
Assignee: NBC MESHTEC INC.
C07D311/64B01J21/04B01J21/063B01J21/18B01J23/30B01J23/42B01J23/44B01J23/462B01J23/468B01J23/50B01J23/52B01J23/72B01J23/745B01J35/0013
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Quick Facts
Patent No.
US 11,434,218
App. No.
16/634,915
Granted
Sep 6, 2022
Kind
B2
Abstract

[PROBLEM] To provide a novel method for synthesising a polyphenol. [SOLUTION] A polyphenol production method including the reaction of catechin in the presence of a catalyst and an oxidising agent, said catalyst comprising a metal oxide and/or a composite that comprises: a substrate which has an inorganic material on the surface thereof; and metal nanoparticles of a particle diameter of 0.5-100 nm attached to the surface of the inorganic material.

Claims (29)

1. A method for producing polyphenol comprising allowing catechins to react in the presence of an oxidizing agent and a catalyst to thereby produce the polyphenol, wherein the catalyst comprises

a metal oxide, and/or

a composite comprising a substrate having a surface comprising an inorganic material and metal nanoparticles adhered to a surface of the inorganic material and having a particle diameter of not less than 0.5 nm and not more than 100 nm,

wherein in the reaction, a molar ratio between the catechins and the oxidizing agent is 1:1 to 1:50,

a concentration of the catechins is 6.4 mM or more, and

a number-average molecular weight of the polyphenol is not less than 9,000 and not more than 18,000.

2. The method for producing polyphenol according to claim 1 , wherein the catalyst comprises the composite, and

the metal nanoparticles are one or more selected from the group consisting of Au, Pd, Pt, Rh, Ru, Ir, Ag, and oxides thereof.

3. The method for producing polyphenol according to claim 1 , wherein the catalyst comprises the composite comprising the metal nanoparticles adhered to a surface of one or more inorganic materials selected from the group consisting of SiO 2 , ZrO 2 , Fe 2 O 3 , Al 2 O 3 , C and TiO 2 .

4. The method for producing polyphenol according to claim 1 , wherein the catalyst comprises one or more metal oxides selected from the group consisting of WO 3 , Fe 2 O 3 , Ag 2 O and CuO.

5. The method for producing polyphenol according to claim 1 , wherein the oxidizing agent is hydrogen peroxide or oxygen.

6. The method for producing polyphenol according to claim 1 , wherein the reaction is carried out in a solvent and is carried out at a temperature of not lower than 15° C. and not higher than the boiling point of the solvent.

7. The method for producing polyphenol according to claim 6 , wherein the solvent is water.

8. A method for producing polyphenol comprising allowing catechins to react in the presence of an oxidizing agent and a catalyst to thereby produce the polyphenol, wherein the catalyst comprises

a metal oxide, and/or

a composite comprising a substrate having a surface comprising an inorganic material and metal nanoparticles adhered to a surface of the inorganic material and having a particle diameter of not less than 0.5 nm and not more than 100 nm, and

wherein a number-average molecular weight of the polyphenol is not less than 9,000 and not more than 18,000.

9. The method for producing polyphenol according to claim 8 , wherein the catalyst comprises the composite, and

the metal nanoparticles are one or more selected from the group consisting of Au, Pd, Pt, Rh, Ru, Ir, Ag, and oxides thereof.

10. The method for producing polyphenol according to claim 8 , wherein the catalyst comprises the composite comprising the metal nanoparticles adhered to a surface of one or more inorganic materials selected from the group consisting of SiO 2 , ZrO 2 , Fe 2 O 3 , Al 2 O 3 , C and TiO 2 .

11. The method for producing polyphenol according to claim 8 , wherein the catalyst comprises one or more metal oxides selected from the group consisting of WO 3 , Fe 2 O 3 , Ag 2 O and CuO.

12. The method for producing polyphenol according to claim 8 , wherein the oxidizing agent is hydrogen peroxide or oxygen.

13. The method for producing polyphenol according to claim 8 , wherein in the reaction, a molar ratio between the catechin and the oxidizing agent is 1:1 to 1:50.

14. The method for producing polyphenol according to claim 8 , wherein the reaction is carried out in a solvent and is carried out at a temperature of not lower than 15° C. and not higher than the boiling point of the solvent.

15. The method for producing polyphenol according to claim 14 , wherein the solvent is water.

16. A method for producing polyphenol comprising allowing catechins to react in the presence of an oxidizing agent and a catalyst to thereby produce the polyphenol, wherein the catalyst comprises

a metal oxide, and/or

a composite comprising a substrate having a surface comprising an inorganic material and metal nanoparticles adhered to a surface of the inorganic material and having a particle diameter of not less than 0.5 nm and not more than 100 nm, and

wherein the oxidizing agent is hydrogen peroxide.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2020
From: TAKAHASHI, ERIKA; FUJIMORI, YOSHIE; JIKIHARA, YOUHEI; NAKAYAMA, TSURUO
To: NBC MESHTEC INC.
Reel/Frame 051661/0363 →
Priority Claims (1)
JP JP2017-163731 · Aug 28, 2017 · national
Continuity (1)
Related Publication 20200231560A1 · Jul 23, 2020