Inhibitors of microbially induced amyloid
The present disclosure provides compounds useful for the prevention of amyloid formation and the treatment of amyloid related disorders, including synucleopathies such as Parkinson's Disease.
1. A compound of Formula (II-a-1) or Formula (II-a-2):
or a pharmaceutically acceptable salt thereof, wherein:
R is H or —CH 3 ;
R 1 is —OH;
R 2 is —H or —CH 3 ;
R 3 is phenyl substituted with n instances of R 4 ;
R 4 is —OH;
n is 0, 1, 2, 3, or 4;
m is 0, 1, 2, 3, or 4; and
the sum of all instances of m and n is 2-9.
2. The compound of claim 1 , wherein
the sum of all instances of m and n is at least three.
3. A compound selected from:
and pharmaceutically acceptable salts thereof.
4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. The compound of claim 1 , wherein R is H.
6. The compound of claim 1 , wherein R 2 is —CH 3 .
7. The compound of claim 1 , wherein m is 1, 2, or 3.