IGF-1 analysis, adjustment and disease management of non-neurological and/or neurological conditions
Described herein are improvements relating to IGF-1 analysis, adjustment and disease management of non-neurological and/or neurological conditions. More specifically, methods relating to the clinical application of cyclic glycine-proline (cGP) biomarker for prediction of risk and recovery of non-neurological and/or neurological conditions with IGF-1 dysfunction and the use of a cGP containing organic or plant based material such as concentrated extract of blackcurrant anthocyanins (BCA) for the treatment of same. The methods more accurately measure IGF-1 function in vivo indirectly using cGP and cGP/IGF-1 ratio along with a means to adjust cGP and cGP/IGF-1 ratio (and hence active IGF-1 concentration), and specific treatment methods for individuals with a lower or reduction of cGP level relative to a standard set of baseline data.
1. A method of treating a stroke or Parkinson's disease in a human in need thereof consisting essentially of:
a) obtaining a biological specimen from the human in need thereof;
b) measuring the concentration of cyclic glycine-proline (cGP) and/or a ratio of cGP concentration to the total measured amount of IGF-1 in the biological specimen from the human in need thereof, as a biomarker for an active, concentration-dependent IGF-1 bioavailability in the biological specimen from the human;
c) comparing either the measured cGP concentration and/or the ratio of cGP concentration to the total measured amount of IGF-1 in the biological specimen from the human to a standard, wherein the standard is based on data collected for a cGP concentration and/or a ratio of cGP concentration to total measured amount of IGF-1 in:
(i) the stroke or Parkinson's disease human; and/or
(ii) a human population of stroke or Parkinson's disease human patients to confirm whether or not the human has an altered cGP concentration and/or ratio of cGP concentration to the total measured amount of IGF-1 compared to the standard;
d) selecting the human for treatment based on the measured cGP concentration or ratio of cGP concentration to total measured amount of IGF-1 compared to the standard; and
e) administering a therapeutically effective amount of a blackcurrant extract to the selected human for treatment, wherein the therapeutically effective amount of the blackcurrant extract is a dose of 50 mg to 1000 mg of the blackcurrant extract to the selected human per day to effectively treat the stroke or the Parkinson's disease in the selected human.
2. The method as claimed in claim 1 , wherein the biological specimen is selected from the group consisting of cerebrospinal fluid, plasma, urine, and tears of the human.
3. The method as claimed in claim 1 , wherein the blackcurrant extract is administered orally or by parenteral administration to the selected human.