Methods and compositions for the treatment of tuberculosis

1. A method of treating tuberculosis in a subject, the method comprising administering to the subject a composition comprising at least one compound selected from the group consisting of:

2. The method of claim 1 , wherein the subject is further administered, or the composition further comprises a compound selected from the group consisting of:

3. The method of claim 1 , wherein the tuberculosis is drug-resistant tuberculosis.

4. The method of claim 3 , wherein the tuberculosis is multiple drug-resistant tuberculosis.

5. The method of claim 3 , wherein the tuberculosis is extensively drug-resistant tuberculosis.

6. A composition comprising at least two compounds selected from the group consisting of Formulas I-IX.

7. The composition of claim 6 , further comprising at least one compound selected from the group consisting of Formulas X-XIII.

8. A method of treating tuberculosis in a subject, the method comprising administering to the subject

a) at least one compound selected from the group consisting of:

and

b) at least one compound selected from the group consisting of rifampicin or pyrazinamide.

9. The method of claim 8 , wherein the tuberculosis is drug-resistant tuberculosis.

10. The method of claim 9 , wherein the tuberculosis is multiple drug-resistant tuberculosis.

11. The method of claim 9 , wherein the tuberculosis is extensively drug-resistant tuberculosis.

12. The method of claim 8 , wherein the compounds of a) and b) are administered separately.

13. The method of claim 8 , wherein the compounds of a) and b) are administered concurrently.

14. A method comprising administering to a subject with tuberculosis a composition comprising at least one compound selected from the group consisting of:

whereby the growth of a Mycobacterium tuberculosis in the subject is inhibited.

15. The method of claim 14 , wherein the subject is further administered, or the composition further comprises a compound selected from the group consisting of:

16. The method of claim 14 , wherein the tuberculosis is drug-resistant tuberculosis.

17. The method of claim 16 , wherein the tuberculosis is multiple drug-resistant tuberculosis.

18. The method of claim 16 , wherein the tuberculosis is extensively drug-resistant tuberculosis.

19. A method comprising administering to a subject with tuberculosis:

a) at least one compound selected from the group consisting of:

b) at least one compound selected from the group consisting of rifampicin or pyrazinamide; whereby the growth of a Mycobacterium tuberculosis in the subject is inhibited.

20. The method of claim 19 , wherein the tuberculosis is drug-resistant tuberculosis.

21. The method of claim 20 , wherein the tuberculosis is multiple drug-resistant tuberculosis.

22. The method of claim 20 , wherein the tuberculosis is extensively drug-resistant tuberculosis.

23. The method of claim 19 , wherein the compounds of a) and b) are administered separately.

24. The method of claim 19 , wherein the compounds of a) and b) are administered concurrently.

25. The method of claim 1 , wherein the administration is oral, by inhalation, intravenous, or intramuscular.

26. The method of claim 14 , wherein the administration is oral, by inhalation, intranasal, intravenous, or intramuscular.

27. The method of claim 19 , wherein the administration is oral, by inhalation, intranasal, intravenous, or intramuscular.