Topical products with a biphasic system
A biphasic topical product comprising a hydrophilic phase and a lipophilic phase floating on said hydrophilic phase. A method for preparing biphasic topical products.
1. A biphasic topical product comprising a mixture of hydroxy acids, trichloroacetic acid and bioactive substances with non-exfoliating activity, wherein the biphasic topical product comprises a hydrophilic phase and a lipophilic phase floating on the hydrophilic phase, the bioactive substances with non-exfoliating activity comprising a mixture of vitamins and amino acids, wherein the hydrophilic phase has a pH between 1 and 2.5 with a tolerance of 0.5 and comprises: tartaric acid at a final concentration by weight of 2% to 15%, citric acid at a final concentration by weight of 0.3% to 5%, salicylic acid at a final concentration by weight of 0.5% to 14%, lactobionic acid at a final concentration by weight of 3% to 13%, and trichloroacetic acid at a final concentration by weight of 5% to 60%, based on the weight of the hydrophilic phase, and wherein the lipophilic phase further comprises at least one wetting and emollient agent selected from isopropyl-myristate and isopropyl-palmitate, and petrolatum oil.
2. The topical product according to claim 1 , wherein the hydrophilic phase further comprises gamma-amino-butyric acid (GABA) or dimethylaminoethanol.
3. The topical product according to claim 2 , wherein the GABA is present at a final concentration by weight of 1% to 10%, or dimethylaminoethanol is present at a final concentration by weight of 0.1% to 1%, all final concentrations based on the weight of the hydrophilic phase.
4. The topical product according to claim 3 , wherein the GABA is present at a final concentration by weight of 2% to 8%, or dimethylaminoethanol is present at a final concentration by weight of 0.2% to 0.8%, all final concentrations based on the weight of the hydrophilic phase.
5. The topical product according to claim 4 , wherein the GABA is present at a final concentration by weight of 3% to 7%, or dimethylaminoethanol is present at a final concentration by weight of 0.3% to 0.7%, all final concentrations based on the weight of the hydrophilic phase.
6. The topical product according to claim 1 , wherein the amino acids present in the hydrophilic phase are selected from glycine, proline, hydroxy-proline, arginine and lysine and the vitamins are riboflavin and vitamin C.
7. The topical product according to claim 6 , wherein the amino acids have a final concentration by weight of 0.01% to 12%, and the vitamins have a final concentration by weight of 0.05% to 2%, all final concentrations based on the weight of the hydrophilic phase.
8. The topical product according to claim 7 , wherein the amino acids have a final concentration by weight of 0.02% to 10%, and the vitamins have a final concentration by weight of 0.06% to 1.5%, all final concentrations based on the weight of the hydrophilic phase.
9. The topical product according to claim 8 , wherein the amino acids have a final concentration by weight of 0.03% to 10%, and the vitamins have a final concentration by weight of 0.07% to 1%, all final concentrations based on the weight of the hydrophilic phase.
10. The topical product according to claim 1 , wherein the tartaric acid is present at a final concentration by weight of 3% to 12%, the citric acid is present at a final concentration by weight of 0.4% to 4%, the salicylic acid is present at a final concentration by weight of 0.75% to 12%, the lactobionic acid is present at a final concentration by weight of 4% to 10%, and trichloroacetic acid has a final concentration by weight of 7% to 55%, all final concentrations based on the weight of the hydrophilic phase.
11. The topical product according to claim 1 , wherein the tartaric acid is present at a final concentration by weight of 4% to 10%, the citric acid is present at a final concentration by weight of 0.5% to 3%, the salicylic acid is present at a final concentration by weight of 1% to 10%, the lactobionic acid is present at a final concentration by weight of 5% to 11%, and trichloroacetic acid has a final concentration by weight of 9% to 50%, all final concentrations based on the weight of the hydrophilic phase.
12. The topical product according to claim 1 , wherein the hydrophilic phase further comprises additives, preservatives, pH adjusters, wetting agents, and rheological modifiers selected from viscosifying and gelling agents.
13. The topical product according to claim 1 , wherein the hydrophilic phase further comprises cationic polymers, silica, ethylenediaminetetraacetic acid (EDTA), potassium hydrogen phosphate, glycerol, wetting agents and sodium hydroxide.
14. The topical product according to claim 1 , wherein the lipophilic phase of the topical product further comprises isopropyl-myristate is at a final concentration of 30% to 75%, and petrolatum oil in a final concentration of 20% to 50%, all final concentrations based on the weight of the lipophilic phase.
15. The topical product according to claim 14 , wherein isopropyl-myristate is at a final concentration of 40% to 70%, and petrolatum oil is at final concentration of 25% to 45%, all final concentrations based on the weight of the lipophilic phase.