Use of peptides as therapeutic agent for autoimmune diseases and bone diseases
The present invention relates to use of peptides as a therapeutic agent, wherein it has been confirmed that the peptides of the present invention significantly inhibit the activity of T cells and the differentiation of T helper 17 cells (Th17 cells), which are associated with autoimmune disease, reduce the secretion of inflammatory cytokine IL-6, and have remarkable effects of treating and improving arthritis in an animal model of arthritis. Therefore, the peptides may be used as an active ingredient in therapeutic agents for various autoimmune diseases such as bone disease, inflammatory disease or rheumatoid arthritis.
1. A synthetic peptide consisting of an amino acid sequence of Formula 1 represented by SEQ ID NO: 1 below:
(X 1 —X 2 —X 3 ) n [Formula 1]
wherein, X 1 is lysine (K),
X 2 is aspartic acid (D),
X 3 is alanine (A), and
n is an integer from 2 to 10.
2. The synthetic peptide according to claim 1 , wherein an N- or C-terminus of the peptide is bound to a protective group selected from the group consisting of an acetyl group, a fluorenylmethoxy carbonyl group, a formyl group, a palmitoyl group, a myristyl group, a stearyl group, and polyethylene glycol (PEG).
3. A method for treating rheumatoid arthritis comprising administering a synthetic peptide consisting of an amino acid sequence of Formula 1 represented by SEQ ID NO: 1 below in a pharmaceutically effective dose to a subject with rheumatoid arthritis:
(X 1 —X 2 —X 3 ) n [Formula 1]
wherein, X 1 is lysine (K),
X 2 is aspartic acid (D),
X 3 is alanine (A), and,
n is an integer from 2 to 10.