IP Library Granted Patent US 11,524,290
Granted Patent B2
US 11,524,290 · App. 16/649,211 · Granted Dec 13, 2022

Discrete volume dispensing system flow rate and analyte sensor

Inventors: Jessica Francis (New Vienna, OH); Mikel Larson (Cincinnati, OH); Michelle D. Hoffman (Wyoming, OH); Eliot Gomez (Cincinnati, OH); Jason Charles Heikenfeld (Cincinnati, OH); Isaac Stamper (Morrow, OH)
Assignees: University Of Cincinnati; Eccrine Systems, Inc.
B01L3/502715A61B5/14507
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Quick Facts
Patent No.
US 11,524,290
App. No.
16/649,211
Granted
Dec 13, 2022
Kind
B2
Abstract

A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel.

Claims (13)

1. A device, comprising:

a chamber including a channel and an opening, wherein the channel is in fluidic communication with the opening;

a wicking component positioned proximate to the opening, wherein the wicking component is configured to receive an amount of biofluid from the channel; and

a sensor configured to measure a characteristic of an analyte in the biofluid, wherein the sensor is in fluidic communication with the wicking component, and wherein the wicking component is configured to contact the sensor with the amount of biofluid, and

wherein the wicking component is positioned no less than 1 μm from the opening.

2. The device of claim 1 further comprising a pump, wherein the pump is in fluidic communication with the wicking component, and wherein the pump is configured to promote contact between the amount of biofluid and the sensor.

3. The device of claim 2 , wherein the pump is configured to absorb the amount of biofluid after the amount of biofluid contacts the sensor.

4. The device of claim μ wherein the wicking component is positioned no more than 1 cm from the opening, and has a diameter of no more than 1 cm and no less than 1 μm.

5. The device of claim 1 , wherein the amount of biofluid is independent of a flow rate of fluid in the channel.

6. The device of claim 1 , wherein the amount of biofluid fluid forms a droplet, wherein the droplet has a convex meniscus when received by the wicking component.

7. The device of claim 1 , wherein the channel is coated with a hydrophobic material.

8. The device of claim 1 , wherein the chamber includes a surface treatment around the opening.

9. The device of claim 8 , wherein the surface treatment includes one of the following: an angled rim; a raised shelf; a hydrophobic coating; and an antimicrobial coating.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 28, 2022
From: ECCRINE SYSTEMS, INC.
To: EPICORE BIOSYSTEMS, INC.
Reel/Frame 059760/0684 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 7, 2021
From: LARSON, MIKEL; HOFFMAN, MICHELLE D.
To: ECCRINE SYSTEMS, INC.
Reel/Frame 057733/0777 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 7, 2021
From: FRANCIS, JESSICA; GOMEZ, ELIOT; HEIKENFELD, JASON CHARLES; STAMPER, ISAAC
To: UNIVERSITY OF CINCINNATI
Reel/Frame 057733/0830 →
Continuity (3)
Provisional Application 62639018 · Mar 6, 2018
Provisional Application 62561335 · Sep 21, 2017
Related Publication 20200298231A1 · Sep 24, 2020