Caffeine production method
The present invention provides a method for producing caffeine, wherein the method comprises: (a) combining a coffee extract comprising caffeine with an aqueous organic acid; (b) crystallizing the coffee extract and the aqueous organic acid so as to form caffeine-organic acid co-crystals in an aqueous phase; (c) separating the caffeine-organic acid co-crystals from the aqueous phase; and (d) extracting caffeine from the co-crystals obtained in step (c), wherein step (d) comprises placing the co-crystals in an aqueous solution so as to form a caffeine precipitate and a solution comprising the organic acid. Also provided is a method for producing a decaffeinated coffee extract comprising chlorogenic acids.
1. A method for producing caffeine, wherein the method comprises:
a. combining a coffee extract comprising caffeine with an aqueous organic acid;
b. crystallizing the coffee extract and the aqueous organic acid so as to form caffeine-organic acid co-crystals in an aqueous phase;
c. separating the caffeine-organic acid co-crystals from the aqueous phase; and
d. extracting caffeine from the co-crystals obtained in step (c);
wherein step (d) comprises placing the co-crystals in an aqueous solution so as to form a caffeine precipitate and a solution comprising the organic acid.
2. The method according to claim 1 , wherein the solution in step (d) is a basic solution with a pH of about 10 to about 14.
3. The method according to claim 1 , wherein step (d) further comprises re-crystallizing caffeine and separating the caffeine crystals from the solution.
4. The method according to claim 3 , wherein the placing of the co-crystals in the solution is carried out at least 5 minutes before re-crystallizing caffeine.
5. The method according to claim 1 , wherein the method further comprises drying the aqueous phase separated from the co-crystals in step (c) so as to form a dried decaffeinated coffee extract.
6. The method according to claim 1 , wherein the method further comprises adding the caffeine extracted in step (d) to a food or beverage product.
7. The method according to claim 1 wherein the method further comprises combining the caffeine extracted in step (d) with at least one of a pharmaceutically acceptable carrier, diluent or excipient to form a pharmaceutical composition.
8. A method for producing a decaffeinated coffee extract comprising chlorogenic acids, wherein the method comprises:
a. combining a coffee extract comprising caffeine and chlorogenic acids with an aqueous organic acid;
b. crystallizing the coffee extract and the aqueous organic acid so as to form caffeine-organic acid co-crystals in an aqueous phase; and
c. separating the caffeine-organic acid co-crystals from the aqueous phase so as to form an aqueous decaffeinated coffee extract comprising chlorogenic acids; and drying the decaffeinated coffee extract comprising chlorogenic acids.
9. The method according to claim 8 , wherein the coffee extract has a caffeine content of at least about 10 wt %.
10. The method according to claim 8 , wherein the coffee extract has a caffeine content of about 10 wt % to about 90 wt %.
11. The method according to claim 8 , wherein the coffee extract is a by-product or side-stream from a coffee decaffeination process.
12. The method according to claim 8 wherein the organic acid is selected from the group consisting of a hydroxybenzoic acid, a derivative of a hydroxybenzoic acid, a derivative of cinnamic acid and mixtures thereof.
13. The method according to claim 8 , wherein the organic acid is a hydroxybenzoic acid.
14. The method according to claim 1 , wherein the organic acid is selected from the group consisting of salicylic acid, gallic acid, vanillic acid, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,4-dihydroxyb enzoic acid, 2,5-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, ellagic acid, caffeic acid, ferulic acid, p-coumaric acid and mixtures thereof.
15. The method according to claim 14 , wherein the organic acid is selected from the group consisting of salicylic acid, gallic acid, vanillic acid, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid and mixtures thereof.
16. The method according to claim 1 , wherein the organic acid is a hydroxybenzoic acid.
17. The method according to claim 16 , wherein the organic acid is selected from the group consisting of salicylic acid, gallic acid, vanillic acid, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, ellagic acid, caffeic acid, ferulic acid, p-coumaric acid and mixtures thereof.