System and method for estimating a treatment volume for administering electrical-energy based therapies
The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
1. A system comprising:
at least one electrode configured to deliver at least one electrical pulse to a target tissue;
a generator in operable communication with the at least one electrode and configured to send the at least one electrical pulse to the at least one electrode; and
a treatment planning module configured to be in operable communication with the generator;
wherein the treatment planning module comprises instructions stored in a memory that, when executed by a processor, cause the processor to measure a response from at least one AC voltage pulse to optimize treatment planning for an electrical energy based treatment comprising at least one DC voltage pulse.
2. The system of claim 1 , wherein the treatment planning module is configured to calculate the specific conductivity of the target tissue based on the measured AC voltage pulse response.
3. The system of claim 1 , wherein the at least one AC voltage pulse is configured to be a test pulse and the at least one DC voltage pulse is capable of inducing non-thermal irreversible electroporation of the target tissue.
4. The system of claim 1 , wherein at least one of the DC voltage pulses is between 1 Hz and 100 MHz.
5. The system of claim 1 , wherein at least one of the AC voltage pulses is in the range of 1 mV to 10 mV.
6. The system of claim 1 , wherein at least one of the AC voltage pulses is between about 50 V and 500 V.
7. The system of claim 1 , wherein the treatment planning module is configured to estimate a target ablation zone.
8. The system of claim 7 , wherein the target ablation zone is estimated using one or more parameters chosen from voltage to distance ratio, edge to edge distance between electrodes, and/or exposure length of the electrode.
9. The system of claim 8 , wherein the target ablation zone is estimated by curve fitting as a function of the one or more parameters.
10. The system of claim 1 , wherein the treatment planning module is configured to derive a baseline conductivity and a maximum conductivity of the treatment area.
11. The system of claim 10 , wherein the baseline conductivity and the maximum conductivity are derived using one or more parameters chosen from voltage to distance ratio, edge to edge distance between electrodes, and/or exposure length of the electrode.
12. The system of claim 10 , wherein the treatment planning module is configured to generate an estimated 3-dimensional treatment volume based on the ratio of the maximum conductivity of the treatment area to the baseline conductivity of the treatment area.
13. The system of claim 12 , further comprising a display device.
14. The system of claim 13 , wherein the display device is configured to display the 3-dimensional treatment volume.
15. The system of claim 1 , further comprising a display.
16. The system of claim 15 , wherein the system is configured to:
measure a baseline and maximum conductivity of the treatment area;
generate a 3-dimensional treatment volume based on the measured baseline and maximum conductivity; and
display the 3-dimensional treatment volume on the display.