Granted Patent B2

US 12,201,349 · App. 17/074,867 · Granted Jan 21, 2025

Inventors: Robert Pearson (San Jose, CA); Mark Ortiz (San Jose, CA); Peter Callas (Castro Valley, CA)

Assignee: AngioDynamics, Inc.

A61B18/1492A61M25/10A61N1/0519A61N1/327A61B2017/00176A61B2018/00214A61B2018/0022A61B2018/00541A61B2018/00577A61B2018/00613A61B2018/00898A61B2018/1425A61B18/1477

Abstract

Claims (46)

1. A method to non-thermally ablate tissue to treat a lung disease, comprising:

advancing a guide sheath to a first treatment zone in a lung of a patient;

operatively coupling an expandable electrode to a generator, wherein the electrode comprises a deployed state and a collapsed state;

operatively coupling a second electrode to the generator;

expanding the electrode from the compressed state to the deployed state at the first treatment zone;

activating the generator programmed to generate a first set of bipolar electrical pulses configured to be delivered through the deployed electrode to the first treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of tissue in the first treatment zone;

collapsing the deployed electrode to the collapsed state;

withdrawing the electrode while in the collapsed state back into the guide sheath;

advancing the guide sheath and the collapsed electrode to a second treatment zone in the lung;

expanding the electrode the deployed state at the second treatment zone;

reactivating the generator programmed to generate a second set of bipolar electrical pulses configured to be delivered through the deployed electrode to the second treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of tissue in the second treatment zone.

2. The method of claim 1 , wherein the guide sheath comprises a steerable endobronchial device.

3. The method of claim 1 , wherein the step of advancing the guide sheath to the first treatment zone further comprises steering the guide sheath under imaging.

4. The method of claim 3 , wherein the imaging further comprises using video assisted 1 magmg.

5. The method of claim 1 , wherein the expandable electrode and the second electrode are both monopolar electrodes.

6. The method of claim 1 , wherein the expandable electrode further comprises a balloon and wherein the non-thermal ablation is irreversible electroporation.

7. The method of claim 1 , wherein the electrode in the deployed state is configured to contact a target tissue in both the first treatment zone and the second treatment zone.

8. The method of claim 1 , wherein the lung disease comprises any of the following: congestive obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, bronchitis, inflammation of the lung airways, or clogged mucus in the bronchial tubes.

9. A method to non-thermally ablate lung tissue comprising:

advancing a guide device to a first treatment zone in the lung; operatively coupling an expandable electrode to a generator;

expanding the electrode from a collapsed state to a deployed state at the first treatment zone;

operatively coupling a second electrode to the generator;

activating the generator programmed to generate a first set of bipolar electrical pulses configured to be delivered through the deployed electrode to the first treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of cells in the first treatment zone;

collapsing the electrode from the deployed state to the collapsed state;

retracting the collapsed electrode back into the guide device;

advancing both the guide device and the collapsed electrode to a second treatment zone in the lung;

expanding the electrode from the collapsed state to the deployed state at the second treatment zone;

reactivating the generator programmed to generate a second set of bipolar electrical pulses configured to be delivered through the deployed electrode to the second treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of cells in the second treatment zone.

10. The method of claim 9 , wherein the expandable electrode and the second electrode are both monopolar electrodes.

11. The method of claim 10 , wherein the expandable electrode in the deployed state is configured to contact a target tissue in both the first treatment zone and the second treatment zone.

12. The method of claim 11 , wherein the expandable electrode is a balloon and the non-thermal ablation is irreversible electroporation.

13. A method to non-thermally ablate lung tissue affected by bronchitis, comprising:

advancing an endobronchial device to a first treatment zone in the lung;

operatively coupling a deployable electrode and a non-deployable electrode to a generator;

expanding the deployable electrode from a collapsed state to a deployed state at the first treatment zone;

activating the generator programmed to generate a first set of bipolar electrical pulses configured to be delivered through the deployed electrode to the first treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of tissue affected by bronchitis in the first treatment zone;

collapsing the electrode from the deployed state to the collapsed state;

retracting the collapsed electrode back into the endobronchial device;

advancing both the endobronchial device and the collapsed electrode to a second treatment zone in the lung;

expanding the electrode from the collapsed state to the deployed state at the second treatment zone;

reactivating the generator programmed to generate a second set of bipolar electrical pulses configured to be delivered through the deployed electrode to the second treatment zone, wherein the bipolar electrical pulses are configured to result in non-thermal ablation of tissue affected by bronchitis in the second treatment zone.

14. The method of claim 13 , wherein the deployable electrode and the non-deployable electrode are monopolar electrodes.

15. The method of claim 13 , wherein the deployable electrode is a balloon and comprises bipolar electrodes.

16. The method of claim 13 , wherein advancing the endobronchial device comprises any of the following procedures: a laparoscopical procedure, a percutaneous procedure, or an endotracheal procedure.

17. The method of claim 13 , wherein the deployed electrode is configured to contact tissue affected by chronic bronchitis in both the first treatment zone and the second treatment zone.

18. The method of claim 13 , wherein the step of advancing the endobronchial device to a first treatment zone further comprises steering the endobronchial device under video assisted 1 magmg.

Assignments (3)

Continuity (5)

References Cited (400)

Cited By (3)

US 12,403,305 US 12,575,879 US 12,685,578