Compositions and methods useful in treatment of lower urinary tract symptoms, benign prostatic hyperplasia, erectile dysfunction and other diseases or symptoms

1. A method of treating or alleviating overactive bladder (OAB), comprising administrating a composition comprising dried cranberry powder to a subject in need thereof at an effective dose and an administration interval such that at least one symptom of OAB is reduced in intensity, severity, or frequency,

wherein the composition is enriched in cranberry seeds or cranberry seed meal, and

wherein the cranberry seeds or cranberry seed meal are present in the therapeutic composition in an amount of about 15% to about 25% by weight of the dried cranberry powder.

2. The method of claim 1 , wherein the at least one symptom is number of micturitions per day.

3. The method of claim 1 , wherein the at least one symptom is number of urgency episodes per day, number of micturitions occurring during the night (nocturia), or mean volumes voided per micturition.

4. The method of claim 1 , wherein the at least one symptom is assessed by changes in OAB Questionnaire—Short Form (OAB-SF), changes in Perception of Bladder Condition (PPBC), changes in Sexual Quality of Life—Female (SQO-F), or changes in Pelvic Floor Distress Inventor (PFDI-20).

5. The method of claim 2 , wherein the number of micturitions per day in the treated subject decreases by at least one compared to a baseline.

6. The method of claim 5 , wherein the number of micturitions per day in the treated subject decreases by about two compared to the baseline.

7. The method of claim 5 or 6 , wherein the baseline is the number of micturitions per day before treatment.

8. The method of claim 1 , wherein the cranberry is Vaccinium macrocarpon.

9. The method of claim 1 , wherein the cranberry is Vaccinium microcarpon.

10. The method of claim 1 , wherein the cranberry is Vaccinium oxycoccus.

11. The method of claim 1 , wherein the cranberry seeds or cranberry seed meal are present in the composition in an amount of about 20% by weight of the dried cranberry powder.

12. The method of claim 1 , wherein the composition comprises less than 12% of organic acids by weight.

13. The method of claim 1 , wherein the composition comprises less than about 15% of sugars by weight.

14. The method of claim 1 , wherein the composition comprises from about 1% to about 5% of quinic acid by weight.

15. The method of claim 1 , wherein the composition comprises from about 0.4% to about 4% of malic acid by weight.

16. The method of claim 1 , wherein the composition comprises from about 1% to about 5% of citric acid by weight.

17. The method of claim 1 , wherein the composition comprises: 0.5% to 5.0% proanthocyanidins, 0.05% to 1.5% quercetin, 0.001% to 0.1% quercetin-3-glucoside, 0.001% to 0.1% quercetin-3-rhamnoside, 0.001% to 0.1% quercetin-3-xyloside, 0.001% to 0.1% quercetin-3-arabinoside, 0.001% to 0.5% myricetin, 0.001% to 0.1% peonidin-3-galactoside, 0.001% to 0.1% peonidin-3-glucoside, 0.001% to 0.1% peonidin-3-arabinoside, 0.001% to 0.1% cyanidin-3-glucoside, 0.001% to 0.1% cyanidin-3-galactoside, 0.001% to 0.1% cyanidin-3-arabinoside, 0.001% to 0.1% protocatechuic acid 0.001% to 0.1% p-coumaric acid, 0.001% to 0.1% caffeoyl-glucoside, 0.001% to 0.1% coumaroyl-glucoside, 0.001% to 0.1% cafeic acid, 0.001% to 0.1% chlorogenic acid or 0.01 to 1.5% ursolic acid by weight.

18. The method of claim 1 , wherein the composition is in a solid oral dosage form.

19. The method of claim 1 , wherein the composition is administered at a dose of between 100 mg to 500 mg.

20. The method of claim 19 , wherein the composition is administered at a dose of 250 mg.

21. The method of claim 19 , wherein the composition is administered at a dose of 500 mg.