IP Library › Granted Patent US 11,357,778
Granted Patent B2
US 11,357,778 · App. 16/662,126 · Granted Jun 14, 2022

Antagonist of the fibroblast growth factor receptor 3 (FGFR3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of FGFR3

Inventors: Laurence Legeai-Mallet (Paris, FR); Arnold Munnich (Paris, FR); Patricia Busca (Paris, FR); Florent Barbault (Paris, FR)
Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITÉ PARIS CITÉ; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS; IMAGINE
A61K31/506B29C48/0017B29C48/022B32B27/302C08J5/18C08L25/06C08L51/04B29K2025/06B29K2035/00B29K2201/00B29L2031/712B32B2262/06B32B2270/00B32B2439/70C08J2325/06C08J2401/00C08J2401/02C08J2425/06C08J2425/08C08J2447/00C08L2203/30C08L2205/02C08L2205/025C08L2205/03C08L2205/035C08L2205/16
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Quick Facts
Patent No.
US 11,357,778
App. No.
16/662,126
Granted
Jun 14, 2022
Kind
B2
Abstract

The present invention relates to the treatment or prevention of skeletal disorders, at particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

Claims (2)

1. A method for treating hypochondroplasia which comprises the step of administering a therapeutically effective amount of an antagonist of the FGFR3 tyrosine kinase receptor of formula:

or a composition comprising a therapeutically effective amount of such an antagonist, to a subject in need thereof.

Assignments (5)
CHANGE OF NAME Recorded Mar 25, 2022
From: UNIVERSITÉ DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 059504/0225 →
MERGER Recorded Jul 22, 2021
From: UNIVERSITE DE PARIS DESCARTES; UNIVERSITE PARIS DIDEROT - PARIS 7
To: UNIVERSITE DE PARIS
Reel/Frame 056947/0567 →
MERGER AND CHANGE OF NAME Recorded Jun 3, 2021
From: UNIVERSITE PARIS DESCARTES; UNIVERSITÉ PARIS DIDEROT - PARIS 7; UNIVERSITE DE PARIS
To: UNIVERSITE DE PARIS
Reel/Frame 056428/0797 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 24, 2019
From: LEGEAI-MALLET, LAURENCE
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Reel/Frame 050810/0811 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 24, 2019
From: MUNNICH, ARNOLD; BUSCA, PATRICIA; BARBAULT, FLORENT
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE PARIS DESCARTES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); ASSISTANCE PUBLIQUE HOPITAUX DE PARIS; UNIVERSITÉ PARIS DIDEROT - PARIS 7; IMAGINE
Reel/Frame 050810/0887 →
Priority Claims (1)
WO PCT/IB2011/003254 · Dec 12, 2011 · international
Continuity (5)
Continuation 15872307 · Jan 16, 2018
Continuation 14844041 · Sep 3, 2015
Continuation 14364320
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