3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

1. A compound of the formula I:

wherein:

X is N or CH;

R 1 is selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) —CN,

(4) —C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

(5) —O—C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

(6) —C≡CH,

(7) —(C═O)—NH 2 , and

(8) —(C═O)—NH(—C 1-6 alkyl);

R 2 is selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) —C 1-6 alkyl, and

(4) —NH 2 ,

or R 1 and R 2 are joined together with a —(CH 2 ) 3 — or —(C═O)(CH 2 ) 2 — to form a 5-membered ring, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

or R 1 and R 2 are joined together with a —(CH 2 ) 4 —, —(C═O)(CH 2 ) 3 —, —(CH 2 )(C═O)(CH 2 ) 2 — to form a 6-membered ring, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro;

R 3 is selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) —CN,

(4) —C 1-6 alkyl, and

(5) —NH 2 ;

R 4 is selected from the group consisting of:

(1) hydrogen,

(2) —CN,

(3) chloro, and

(4) fluoro;

R 5 is selected from the group consisting of:

(1) hydrogen, and

(2) —CH 3 ;

R 6 is selected from the group consisting of:

(1) hydrogen,

(2) —C 1-6 alkyl, which is unsubstituted or substituted with a —CN, 1-3 fluoro, or phenyl which is unsubstituted or substituted with a hydroxy or a —SO 2 —NH 2 ,

(3) —C 3-6 cycloalkyl, which is unsubstituted or substituted with a —CN, or —(C═O)—NH 2 ;

(4) —(CH 2-5 cycloalkyl-O—),

(5) —C 1-6 alkyl-C 3-6 cycloalkyl,

(6) —C 1-6 alkyl-(CH 2-5 cycloalkyl-O—),

(7) —C 1-6 alkyl-O—C 1-6 alkyl,

(8) —C 1-6 alkyl-C≡CH,

(9) —C 1-6 alkyl-C 1-6 alkyl, and

(10) phenyl;

each of R 7 and R 8 is independently selected from the group consisting of:

(1) hydrogen, and

(2) C 1-6 alkyl,

or R 7 and R 8 taken together form a keto group;

or a pharmaceutically acceptable salt thereof;

with the proviso that the compound is other than:

6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is N.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is CH.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of:

(1) hydrogen,

(2) fluoro,

(3) chloro,

(4) —CN, and

(5) methyl.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from the group consisting of:

(1) hydrogen, and

(2) methyl.

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are joined together with a —(CH 2 ) 3 — to form a 5-membered ring, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from the group consisting of:

(1) hydrogen,

(2) —CN, and

(2) methyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is selected from the group consisting of:

(1) hydrogen,

(2) —C 1-6 alkyl, which is unsubstituted or substituted with a —CN, 1-3 fluoro, or phenyl which is unsubstituted or substituted with a hydroxy or a —SO 2 —NH 2 , and

(3) —C 1-6 alkyl-C 3-6 cycloalkyl.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is hydrogen and R 8 is hydrogen.

10. A compound which is selected from the group consisting of:

3-(6-fluoro-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(R)-6-(cyclopropylmethyl)-3-(7-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-6-(cyclopropylmethyl)-3-(7-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-(cyclopropylmethyl)-isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-phenethylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-((tetrahydrofuran-2-yl)methyl)isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-cyclopropylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-4-fluoropyridin-2-yl)-2-(cyclopropylmethyl)-isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-5-fluoro-1H-pyrazol-4-yl)pyridin-2-yl)-2-(cyclopropylmethyl)-isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-5-fluoro-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-(cyclopropylmethyl)isoindolin-1-one;

6-(cyclopropylmethyl)-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-methyl-3-oxoisoindolin-5-yl)picolinonitrile;

5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)-N-methylpicolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-cyclopropyl-3-oxoisoindolin-5-yl)-N-methylpicolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-N-methyl-6-(2-methyl-3-oxoisoindolin-5-yl)picolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)picolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-cyclopropyl-3-oxoisoindolin-5-yl)picolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-methyl-3-oxoisoindolin-5-yl)picolinamide 5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)picolinonitrile;

5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(2-cyclopropyl-3-oxoisoindolin-5-yl)picolinonitrile;

5-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-(3-oxoisoindolin-5-yl)picolinonitrile;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-fluoropyridin-2-yl)-2-(cyclopropylmethyl)isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-fluoropyridin-2-yl)-2-methylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-fluoropyridin-2-yl)-2-cyclopropylisoindolin-1-one;

6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-methyl-6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-cyclopropyl-6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-methyl-6-(6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-cyclopropyl-6-(6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-(cyclopropylmethyl)-6-(4-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

2-(cyclopropylmethyl)-6-(3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)isoindolin-1-one;

2-(2-methyl-3-oxoisoindolin-5-yl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)isonicotinonitrile;

6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(2-cyclopropyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(3-oxoisoindolin-5-yl)picolinonitrile;

methyl 2-(6-(6-cyano-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1-oxoisoindolin-2-yl)acetate;

2-cyclopropyl-6-(6-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-(6-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(6-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-(6-chloro-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

2-methyl-6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)isoindolin-1-one;

(R)-3-(7-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

(S)-3-(7-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(6-chloro-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-(5-fluoro-6-(hydroxymethyl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(2-(2-fluoroethyl)-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

5-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(2-methyl-3-oxoisoindolin-5-yl)picolinonitrile;

5-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(3-oxoisoindolin-5-yl)picolinonitrile;

6-(2-cyclopropyl-3-oxoisoindolin-5-yl)-5-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)-5-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(5,6-difluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-fluoro-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(2-(cyclopropylmethyl)-3-oxoisoindolin-5-yl)-3-fluoro-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

2-(2-fluoroethyl)-6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)isoindolin-1-one;

6-(5-fluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-amino-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(6-(fluoromethyl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(6-fluoro-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

5-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(6-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)picolinonitrile;

6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)isoindolin-1-one;

3-(6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-1-oxoisoindolin-2-yl)propanenitrile;

6-(6-fluoro-3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-(6-(fluoromethyl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(6-fluoro-3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(1,1,2-trimethyl-3-oxoisoindolin-5-yl)picolinonitrile;

6-methyl-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(4-amino-6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(4-amino-6-chloro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(1,1-dimethyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

2-(cyclopropylmethyl)-6-(6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-(2-fluoroethyl)-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(fluoromethyl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(fluoromethyl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-(3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)propanenitrile;

6-(2-methoxyethyl)-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6,7,7-trimethyl-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(1,1,2-trimethyl-3-oxoisoindolin-5-yl)picolinonitrile;

2-(2-methoxyethyl)-6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)isoindolin-1-one;

3-(3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(6-chloro-3-(5-fluoro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-5-methylpyridin-2-yl)-2-methylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-5-fluoro-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-methylisoindolin-1-one;

6-(6-(hydroxymethyl)-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-chloro-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

5-(5-chloro-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(2-methyl-3-oxoisoindolin-5-yl)picolinonitrile;

3-(6-(difluoromethyl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-methyl-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(2-(oxetan-3-yl)-3-oxoisoindolin-5-yl)picolinonitrile;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-phenylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-(cyclopropylmethyl)isoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-((tetrahydrofuran-2-yl)methyl)isoindolin-1-one;

2-(cyclobutylmethyl)-6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

1-(6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1-oxoisoindolin-2-yl)cyclopropane-1-carbonitrile;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-(oxetan-3-yl)isoindolin-1-one;

2-cyclobutyl-6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

1-(6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1-oxoisoindolin-2-yl)-N-methylcyclopropane-1-carboxamide 4-(2-(6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1-oxoisoindolin-2-yl)ethyl)benzenesulfonamide 6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-phenethylisoindolin-1-one;

6-(3-(1-(cyclopentyl-methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-cyclopropylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-(4-hydroxyphenethyl)isoindolin-1-one;

6-(6-Methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)-6-methylpyridin-2-yl)-2-methylisoindolin-1-one;

2-methyl-5-(6-methyl-3-(1 #1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindoline-1,3-dione;

5-(6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindoline-1,3-dione;

3-(6-chloro-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-methyl-6,7-dihydro-5H-pyrrolo [3,4-b]pyridin-5-one;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)picolinonitrile;

6-(6-(cyclopropylmethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(6-(2-fluoroethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-(1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-(6-cyclopropyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

3-(6-chloro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-(cyclopropylmethyl)-6,7-dihydro-5H-pyrrolo [3,4-b]pyridin-5-one;

6-(6-chloro-3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(6-chloro-3-(1-(cyclopentylmethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-cyclopropylisoindolin-1-one;

6-(5,6-dimethyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

5-(3-cyano-1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(2-methyl-3-oxoisoindolin-5-yl)picolinonitrile;

3-methyl-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

3-methyl-6-(6-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)-methyl)-1H-pyrazol-4-yl)picolinonitrile;

3-methyl-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(3-oxoisoindolin-5-yl)picolinonitrile;

3-methyl-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinamide 5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(3-oxoisoindolin-5-yl)picolinamide 6-(6-(fluoromethyl)-5-methyl-3-(14(1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(5-fluoro-6-(fluoromethyl)-3-(1-((1-methylcyclo-pentyl)-methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(6-(methoxymethyl)-5-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

3-(6-(fluoromethyl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6-(prop-2-yn-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-(prop-2-yn-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(2-fluoroethyl)-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

6-(but-2-yn-1-yl)-3-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(5-oxo-6-(prop-2-yn-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)picolinonitrile;

5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6-(3-oxo-2-(prop-2-yn-1-yl)isoindolin-5-yl)picolinonitrile;

6-(6-isopropyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(6-(but-2-yn-1-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-2-(prop-2-yn-1-yl)isoindolin-1-one;

2-(2-methyl-3-oxoisoindolin-5-yl)-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one;

3-chloro-6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(4-fluoro-6-methyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one;

6-(5,6-difluoro-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylisoindolin-1-one; and

6-(cyclopropylmethyl)-3-(6-ethynyl-3-(1-((1-methylcyclopentyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

or a pharmaceutically acceptable salt thereof.

11. A pharmaceutical composition which comprises an inert carrier and a compound of claim 1 , or a pharmaceutically acceptable salt thereof.