IP Library Granted Patent US 11,197,894
Granted Patent B2
US 11,197,894 · App. 16/679,908 · Granted Dec 14, 2021

Nanofraction immune modulators, preparations and compositions including the same, and associated methods

Inventors: David A. Lisonbee (Orem, UT); Calvin W. McCausland (Springville, UT); Richard H. Bennett (Captain Cook, HI); Brent M. Vaughan (Draper, UT); Shane M. Lefler (American Fork, UT)
Assignee: 4Life Patents, LLC
A61K35/20A23L33/10A23L33/17A61K35/57G01N33/505G01N2333/70514
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Quick Facts
Patent No.
US 11,197,894
App. No.
16/679,908
Granted
Dec 14, 2021
Kind
B2
Abstract

Compositions that include extracts from sources of immune modulators that include nanofraction immune modulator molecules (i.e., molecules having molecular weights of about 3,000 Da and less) are disclosed. These compositions may also include other immune modulators, such as transfer factor. Administration of compositions with extracts that include nanofraction immune modulator molecules modulates the cell-mediated immunity (e.g., down-regulates undesired T cell activity) of a subject to which such compositions are administered. When administered with transfer factor, the combination of nanofraction immune modulator molecules and transfer factor down-regulates undesired T cell activity while increasing, or up-regulating, T cell activity against pathogens and other undesirable entities, such as cancer cells and other aberrant or mutated cells. Assays and assay techniques for evaluating the immune modulation capabilities of various substances are also disclosed.

Claims (16)

1. A composition comprising an immune modulating component consisting of:

a first fraction of a first quantity of bovine colostrum, the first fraction having a first upper molecular weight cutoff of about 10,000 Da;

a second fraction of a second quantity of bovine colostrum, the second quantity being separate from the first quantity, the second fraction having a second upper molecular weight cutoff of about 4,000 Da obtained by separating molecules having molecular weights at and below the second upper molecular weight cutoff from molecules having molecular weights above the second upper molecular weight cutoff; and

egg yolk,

the first fraction, the second fraction, and the egg yolk being combined with one another.

2. The composition of claim 1 , wherein:

the first fraction includes transfer factor and immune modulators; and

the second fraction includes immune modulators.

3. The composition of claim 1 , wherein the egg yolk is chicken egg yolk.

4. The composition of claim 1 , wherein the egg yolk is in a dried form.

5. The composition of claim 4 , wherein the first fraction and the second fraction are in dried forms.

6. The composition of claim 5 , wherein:

the first fraction makes up about 68% of the total weight of the immune modulating component;

the second fraction makes up about 2% of the total weight of the immune modulating component; and

the egg yolk makes up about 30% of the total weight of the immune modulating component.

7. The composition of claim 1 , wherein the first fraction is obtained by separating molecules having molecular weights at and below the first upper molecular weight cutoff from molecules having molecular weights above the first upper molecular weight cutoff.

Assignments (5)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 28, 2020
From: LISONBEE, DAVID; MCCAUSLAND, CALVIN W.; BENNETT, RICHARD H.; VAUGHAN, BRENT M.; LEFLER, SHANE M.
To: 4LIFE PATENTS, LLC
Reel/Frame 051958/0486 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2020
From: LISONBEE, DAVID; MCCAUSLAND, CALVIN W.; BENNETT, RICHARD H.; VAUGHAN, BRENT M.; LEFLER, SHANE M.
To: 4LIFE PATENTS, LLC
Reel/Frame 051958/0510 →
NUNC PRO TUNC ASSIGNMENT Recorded Feb 28, 2020
From: 4LIFE PATENTS, LLC
To: 4LIFE RESEARCH, LC
Reel/Frame 051958/0538 →
NUNC PRO TUNC ASSIGNMENT Recorded Feb 28, 2020
From: 4LIFE RESEARCH, LLC
To: 4LIFE PATENTS, LLC
Reel/Frame 051958/0546 →
CHANGE OF NAME Recorded Feb 28, 2020
From: 4LIFE RESEARCH, LC
To: 4LIFE RESEARCH, LLC
Reel/Frame 051958/0550 →
Continuity (3)
Continuation 11855944 · Sep 14, 2007
Provisional Application 60848348 · Sep 29, 2006
Related Publication 20200069737A1 · Mar 5, 2020