Formulation based on vitamin E or an ester thereof for treating bacterial and fungal biofilms
Formulations for topical use based on vitamin E or an ester thereof for use in removing, reducing or inhibiting a bacterial and/or fungal biofilm, are disclosed. The ester of vitamin E is an ester with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having from 1 to 19 carbon atoms, or an alkenyl or alkynyl having from 2 to 19 carbon atoms.
1. A method of removing, reducing or inhibiting a bacterial biofilm on an area of a patient's skin, comprising topically applying a formulation selected from the group consisting of vitamin E and an ester thereof to the area of the skin requiring such treatment.
2. The method of claim 1 , wherein said ester of vitamin E is an ester with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having from 1 to 19 carbon atoms, or an alkenyl or alkynyl having from 2 to 19 carbon atoms.
3. The method of claim 2 , wherein said ester is alpha-tocopheryl acetate, n-propionate or linoleate.
4. The method of claim 3 , wherein said ester is alpha-tocopheryl acetate.
5. The method of claim 1 , wherein said formulation consists of vitamin E acetate.
6. The method of claim 1 , wherein said formulation consists of alpha-tocopheryl acetate.
7. The method of claim 1 , wherein said formulation is applied to the area requiring treatment daily.
8. The method of claim 7 , wherein the amount of the formulation applied to the skin daily is from 0.1 to 10 g/10 cm 2 of skin.
9. The method of claim 8 , wherein the amount of the formulation applied to the skin daily is from 0.5 to 2.5 g/10 cm 2 of skin.
10. The method of claim 9 , wherein the amount of the formulation applied to the skin daily is from 0.8 to 1.2 g/10 cm 2 of skin.
11. A method of removing, reducing or inhibiting a bacterial biofilm on an area of a patient's skin, which comprises topically applying a formulation consisting of in weight percentages on the total weight of the formulation,
20 to 70% of vitamin E acetate,
20 to 70% of a volatile silicone,
7 to 13% of hydrogenated castor oil,
7 to 15% of an oily component selected from the group consisting of vegetable oils, and esters of fatty acids, said esters of fatty acids being selected from the group consisting of octyl palmitate, isopropyl myristate and ethyl oleate and mixtures thereof, and
2 to 3% of dimethiconol,
to the area of skin requiring such treatment.
12. The method of claim 11 , wherein said volatile silicone is selected from the group consisting of pentamer cyclomethicone, tetramer cyclomethicone, hexamer cyclomethicone, hexamethyldisiloxane, low viscosity dimethicone and mixtures thereof.
13. The method of claim 11 , wherein the amount of the formulation applied to the skin daily is from 0.15 to 20 g/10 cm 2 of skin.
14. The method of claim 13 , wherein the amount of the formulation applied to the skin daily is from 1.0 to 7 g/10 cm 2 of skin.
15. The method of claim 14 , wherein the amount of the formulation applied to the skin daily is from 1.5 to 5 or from 3 g to 4 g/10 cm 2 of skin.
16. A method of removing, reducing or inhibiting a bacterial biofilm on an area of a patient's skin having a burn wound thereon, comprising topically applying a formulation consisting of in weight percentages on the total weight of the formulation,
20 to 70% of vitamin E acetate,
20 to 70% of a volatile silicone,
7 to 13% of hydrogenated castor oil,
7 to 15% of an oily component selected from the group consisting of vegetable oils, and esters of fatty acids, said esters of fatty acids being selected from the group consisting of octyl palmitate, isopropyl myristate and ethyl oleate and mixtures thereof, and
2 to 3% of dimethiconol,
to the area of skin requiring such treatment.
17. A method of removing, reducing or inhibiting a bacterial biofilm on an area of a patient's skin having a burn wound thereon, comprising topically applying a formulation selected from the group consisting of vitamin E and an ester thereof to the area of skin requiring such treatment.