Thermally controlled residence devices

1. A residence device comprising:

a plurality of links, wherein at least a portion of the plurality of links include:

a first link segment;

a second link segment; and

a coupling that selectively connects the first link segment to the second link segment, and wherein the coupling is configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature; and

a plurality of flexible hinges, wherein each hinge pivotably connects at least two links of the plurality of links to form a flexible structure such that the residence device is reconfigurable from a first contracted configuration to a second expanded configuration, wherein the residence device is configured to be retained in a stomach of a subject in the second expanded configuration, and wherein the threshold temperature is greater than normothermia of the stomach.

2. The residence device of claim 1 , wherein the plurality of links include a therapeutic compound.

3. The residence device of claim 2 , wherein the plurality of links are configured to release the therapeutic compound in vivo at a rate between or equal to 100 mg/day and 400 mg/day.

4. The residence device of claim 2 , wherein the plurality links include an amount of the therapeutic compound between or equal to 1 g and 5 g.

5. The residence device of claim 1 , further comprising a sensor attached to a portion of the residence device.

6. The residence device of claim 1 , wherein the plurality of links form a three-dimensional structure in the second expanded configuration.

7. The residence device of claim 6 , wherein the plurality of links form a cylindrical structure in the first contracted configuration.

8. The residence device of claim 1 , wherein a minimum dimension of the residence device in the contracted configuration is less than 18 mm and a minimum dimension of the residence device in the expanded configuration is greater than 20 mm.

9. The residence device of claim 1 , wherein the residence device is configured to disassemble into fragments with a maximum dimension less than or equal to 2 cm when the couplings are exposed to a temperature greater than the threshold temperature.

10. A method of using a residence device, the method comprising:

introducing a residence device in a first contracted configuration into a stomach of a subject;

reconfiguring the residence device into a second expanded configuration once the residence device is located in the stomach; and

exposing the residence device to a temperature greater than a threshold temperature to selectively weaken or disassemble at least a portion of the residence device, wherein exposing the residence device to a temperature greater than a threshold temperature includes exposing the residence device to a temperature greater than normothermia of the stomach.

11. The method of claim 10 , further comprising releasing a therapeutic compound from the residence device while the residence device is located in the stomach.

12. The method of claim 11 , wherein releasing the therapeutic compound includes releasing the therapeutic compound at a rate between or equal to 100 mg/day and 400 mg/day.

13. The method of claim 11 , wherein releasing the therapeutic compound includes releasing an amount of the therapeutic compound between or equal to 1 g and 5 g while the residence device is located in the stomach.

14. The method of claim 10 , further comprising sensing one or more parameters with the residence device while the residence device is located in the stomach.

15. The method of claim 10 , further comprising deploying the residence device into the stomach through an esophagus of the subject.

16. The method of claim 10 , further comprising passing fragments of the residence device through a pylorus of the subject to remove the residence device from the stomach.

17. A residence device, the device comprising:

a plurality of links;

a plurality of flexible hinges, each hinge configured to pivotably connect at least two links of the plurality of links to form a flexible structure such that the residence device is reconfigurable from a first contracted configuration to a second expanded configuration; and

two or more dissolvable capsules, wherein a first portion of the residence device is disposed in a first dissolvable capsule, a second portion of the residence device is disposed in a second dissolvable capsule, followed by any number of portions disposed in a subsequent capsule, and a resultant portion of the residence device extending between the dissolvable capsules, and wherein when the first and second dissolvable capsules dissolve, the residence device expands from the first contracted configuration to the second expanded configuration.

18. The residence device of claim 17 , wherein the plurality of links form a three-dimensional structure in the second expanded configuration.

19. The residence device of claim 18 , wherein the plurality of links form a cylindrical structure in the first contracted configuration.

20. The residence device of claim 19 , wherein a minimum dimension of the residence device in the contracted configuration is less than 18 mm and a minimum dimension of the residence device in the expanded configuration is greater than 20 mm.

21. The residence device of claim 17 , wherein at least a portion of the plurality of links include:

a first link segment;

a second link segment; and

a coupling that selectively connects the first link segment to the second link segment, and wherein the coupling is configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature.

22. The residence device of claim 1 , wherein the threshold temperature is greater than or equal to 45 degrees Celsius.

23. The method of claim 10 , wherein the threshold temperature is greater than or equal to 45 degrees Celsius.