UTILITY OF NEMATODE SMALL MOLECULES
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
1 - 19 . (canceled)
20 . A method of decreasing cellular infiltration into lungs in a subject afflicted with asthma comprising administering an ascaroside to the subject.
21 . The method of claim 20 , wherein the infiltration of inflammatory cells into lungs of the subject is decreased.
22 . The method of claim 21 , wherein the inflammatory cells are eosinophils.
23 . The method of claim 21 , wherein the inflammatory cells are lymphocytes.
24 . The method of claim 21 , wherein the inflammatory cells are eosinophils and lymphocytes.
25 . The method of claim 20 , wherein the method is a method of treating asthma in the subject.
26 . The method of claim 20 , wherein the ascaroside is selected from ascr#1, ascr#3, ascr#7, ascr#8, ascr#9, and ascr#10.
27 . The method of claim 20 , wherein the subject is selected from primates, humans, equines, horses, cattle, cows, swine, sheep, rodents, rats, pets, dogs, and guinea pigs.
28 . The method of claim 20 , wherein the subject is a human.
29 . A method of reducing expression of genes associated with mucus production in a subject comprising administering an ascaroside to the subject.
30 . The method of claim 29 , wherein the mRNA level of the gene associated with mucus production is reduced.
31 . The method of claim 29 , wherein the gene associated with mucus production is selected from Gob5, Muc5a/c and Muc5b.
32 . The method of claim 29 , wherein the method is a method of treating asthma in the subject.
33 . The method of claim 29 , wherein the ascaroside is selected from ascr#1, ascr#3, ascr#7, ascr#8, ascr#9, and ascr#10.
34 . The method of claim 29 , wherein the subject is selected from primates, humans, equines, horses, cattle, cows, swine, sheep, rodents, rats, pets, dogs, and guinea pigs.
35 . The method of claim 29 , wherein the subject is a human.
36 . An isolated compound of Formula I′ or Formula I″:
R 1 is H or —C(R) 3 ;
each R is H;
R 1′ is H or —C(R) 3 ;
R 2 is a moiety of formula
R 3 and R 4 are each independently H, a monosaccharide having 5 or 6 carbon atoms, or a bond connecting to R 5 of another unit of Formula I;
each R 5 is independently H, —OH, —CR 6 R 7 R 8 , a monosaccharide having 5 or 6 carbon atoms, or a bond connecting to R 3 or R 4 of another unit of Formula I;
R 6 and R 7 are each H;
R 8 is H;
n 1 and n 3 are each independently an integer of 0 to 13;
n 2 is 0;
n 4 is 1; and
the sum of n 1 and n 3 is 7 to 13.