COMPOSITION FOR INHIBITING IMMUNE CELL PROLIFERATION COMPRISING SIALYLLACTOSE OR DERIVATIVE THEREOF AND METHOD THEREOF

1 : A method of inhibiting immune cell proliferation, the method comprising administering a therapeutically effective amount of a composition containing sialyllactose or a pharmaceutically acceptable salt thereof as an active ingredient to a patient in need of treatment.

2 : The method of claim 1 , wherein the sialyllactose is 3′-sialyllactose or 6′-sialyllactose.

3 : The method of claim 2 , wherein the salt of 3′-sialyllactose has a structure of the following Formula 1:

4 : The method of claim 2 , wherein the salt of 6′-sialyllactose has a structure of the following Formula 2:

5 : The method of claim 1 , wherein the method has prophylactic or therapeutic effects on atopic dermatitis or rheumatoid arthritis.

6 : The method of claim 1 , wherein the method has one or more of the following characteristics of:

1) increasing expression of type II collagen (Col2a1);

2) decreasing expression of matrix metalloproteinase3 (Mmp3) or matrix metalloproteinase13 (Mmp13);

3) increasing Sox-9 activity; and

4) increasing inactivation of p-ERK.

7 : The method of claim 1 , wherein the method has one or more of the following characteristics of:

1) decreasing expression of chemokines;

2) decreasing expression of pro-inflammatory cytokines;

3) decreasing production of inflammatory mediators;

4) decreasing expression of COX2; and

5) decreasing production of PEG 2 .

8 : The method of claim 1 , wherein the method has one or more of the following characteristics of:

1) inhibiting synovial hyperplasia; and

2) inhibiting infiltration of mononuclear cells.

9 : The method of claim 1 , further comprising a pharmaceutically acceptable carrier, excipient, or diluent.

10 - 20 . (canceled)