System and method for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand
Systems and methods are disclosed for to determining a blood supply and blood demand. One method includes receiving a patient-specific model of vessel geometry of at least a portion of a coronary artery, wherein the model is based on patient-specific image data of at least a portion of a patient's heart having myocardium; determining a coronary blood supply based on the patient-specific model; determining at least a portion of the myocardium corresponding to the coronary artery; determining a myocardial blood demand based on either a mass or a volume of the portion of the myocardium, or based on perfusion imaging of the portion of the myocardium; and determining a relationship between the coronary blood supply and the myocardial blood demand.
1. A computer-implemented method of determining a blood supply and a blood demand, the method comprising:
receiving a patient-specific model of vessel geometry of at least a portion of an artery, wherein the model is based on patient-specific image data;
computing a volume of the artery, based on the patient-specific model;
computing a patient-specific arterial supply capacity based on the computed volume of the artery;
determining a mass or a volume of at least a portion of a tissue or organ receiving blood from the artery;
determining an amount of blood demanded by the mass or the volume of the portion of the tissue or the organ; and
evaluating the patient based on a comparison between the computed volume of the artery and the amount of blood demanded by the tissue or the organ.
2. The method of claim 1 , further comprising:
determining, based on the comparison, a disease state of the patient.
3. The method of claim 1 , further comprising:
identifying, based on the comparison, a mismatch between the volume of the artery and the amount of blood demanded by the mass or the volume; and
determining, based on the mismatch, a relationship between the patient's arterial supply and the patient's tissue or organ demand.
4. The method of claim 3 , further comprising:
based on the identified mismatch, modifying at least one parameter of a patient-specific simulation of blood flow through at least the portion of the artery.
5. The method of claim 1 , further comprising:
receiving a second patient-specific model representing arterial vasculature downstream from the portion of the artery; and
determining the amount of blood supplied by the artery, based on the patient-specific model and the second patient-specific model.
6. The method of claim 5 , wherein the second patient-specific model is generated based upon boundaries of a tissue associated with at least a portion of the artery.
7. The method of claim 1 , wherein the mass of the portion of the tissue or organ is calculated at least in part by measuring or assuming a tissue density of the portion of the tissue or organ.
8. The method of claim 1 , wherein the patient-specific model is generated by modifying a generic model of vessel geometry.
9. A system for image processing to determine a blood supply and a blood demand, the system comprising:
a data storage device storing instructions for determining the blood supply and the blood demand; and
a processor configured to execute the instructions to perform a method including:
receiving a patient-specific model of vessel geometry of at least a portion of an artery, wherein the model is based on patient-specific image data;
computing a volume of the artery, based on the patient-specific model;
computing a patient-specific arterial supply capacity based on the computed volume of the artery;
determining a mass or a volume of at least a portion of a tissue or organ receiving blood from the artery;
determining an amount of blood demanded by the mass or the volume of the portion of the tissue or the organ; and
evaluating the patient based on a comparison between the computed volume of the artery and the amount of blood demanded by the tissue or the organ.
10. The system of claim 9 , wherein the system is further configured for:
determining, based on the comparison, a disease state of the patient.
11. The system of claim 9 , wherein the system is further configured for:
identifying, based on the comparison, a mismatch between the volume of the artery and the amount of blood demanded by the mass or the volume; and
determining, based on the mismatch, a relationship between the patient's arterial supply and the patient's tissue or organ demand.
12. The system of claim 11 , wherein the system is further configured for:
modifying, based on the identified mismatch, at least one parameter of a patient-specific simulation of blood flow through at least the portion of the artery.
13. The system of claim 9 , wherein the system is further configured for:
receiving a second patient-specific model representing arterial vasculature downstream from the portion of the artery; and
determining the amount of blood supplied by the artery, based on the patient-specific model and the second patient-specific model.
14. The system of claim 13 , wherein the second patient-specific model is generated based upon boundaries of a tissue associated with at least a portion of the artery.
15. The system of claim 9 , wherein the mass of the portion of the tissue or organ is calculated at least in part by measuring or assuming a tissue density of the portion of the tissue or organ.
16. The system of claim 9 , wherein the patient-specific model is generated by modifying a generic model of vessel geometry.
17. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of determining a blood supply and a blood demand, the method comprising:
receiving a patient-specific model of vessel geometry of at least a portion of an artery, wherein the model is based on patient-specific image data;
computing a volume of the artery, based on the patient-specific model;
computing a patient-specific arterial supply capacity based on the computed volume of the artery;
determining a mass or a volume of at least a portion of a tissue or organ receiving blood from the artery;
determining an amount of blood demanded by the mass or the volume of the portion of the tissue or the organ; and
evaluating the patient based on a comparison between the computed volume of the artery and the amount of blood demanded by the tissue or the organ.