Topical composition containing antioxidants
Compositions for topical application that effectively deliver antioxidants across the epidermis, dermis, or a combination thereof into cells and/or the bloodstream while concurrently maintaining chemical activity of the antioxidants. In certain aspects, these formulations include emulsions and balms each having a lipophilic carrier and a lipophilic antioxidant solubilized by the lipophilic carrier. Also disclosed herein are methods for making these compositions for topical application.
1. A method of making a topical composition comprising:
mixing a lipophilic antioxidant comprising at least one phenyl group and a lipophilic carrier to create a butter and heating to 230-275° F. for about five minutes;
mixing water and glycerin in a container and heating to between 150-200° F. to create a water-glycerin mixture;
mixing the butter with a surfactant, a mineral oil, a paraffinic oil, an antioxidant, a skin penetration enhancer and heating to between 150-200° F. to create an oil-based mixture;
mixing a preservative with a fragrance to create a preservative mixture;
mixing the water-glycerin mixture with the oil-based mixture to create an emulsion and reducing temperature; and
mixing in the preservative mixture once temperature has reached about 160° F. and cooling to room temperature.
2. The method of claim 1 wherein the lipophilic antioxidant is pentaerythritol tetrakis (3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate).
3. The method of claim 1 wherein the lipophilic carrier is avocado butter.
4. The method of claim 1 wherein the paraffinic oil is petrolatum.
5. The method of claim 1 wherein the antioxidant is vitamin E.
6. The method of claim 1 wherein the skin penetration enhancer comprises at least one derivative of stearic acid.
7. The method of claim 1 wherein the preservative mixture comprises propylene glycol, diazolidinyl urea, methylparaben, and propylparaben.