Disc therapy
Apparatus is provided that includes one or more intra-pulposus exposed electrode surfaces, and a support structure along which the one or more intra-pulposus exposed electrode surfaces are disposed. The support structure is configured to be implanted within a nucleus pulposus of an intervertebral disc of a subject, and to be shaped as a partial ring or a complete ring after implantation. The apparatus further includes one or more extra-pulposus exposed electrode surfaces, which are configured to be implanted outside the nucleus pulposus, in electrical communication with the disc. Control circuitry is provided, which is configured to: configure the intra-pulposus exposed electrode surfaces to be cathodes, and the one or more extra-pulposus exposed electrode surfaces to be one or more anodes, and drive the intra-pulposus exposed electrode surfaces and the one or more extra-pulposus exposed electrode surfaces to electroosmotically drive fluid into the nucleus pulposus. Other embodiments are also described.
1. Apparatus for treating an intervertebral disc of a subject, the apparatus comprising:
one or more intra-pulposus exposed electrode surfaces;
a support structure along which the one or more intra-pulposus exposed electrode surfaces are disposed, wherein the support structure is configured to be implanted within a nucleus pulposus of the disc, and to be shaped as a partial ring or a complete ring after implantation;
one or more extra-pulposus exposed electrode surfaces, which are configured to be implanted outside the nucleus pulposus, in electrical communication with the disc; and
control circuitry, which is configured to:
configure the intra-pulposus exposed electrode surfaces to be cathodes, and the one or more extra-pulposus exposed electrode surfaces to be one or more anodes, and
drive the intra-pulposus exposed electrode surfaces and the one or more extra-pulposus exposed electrode surfaces to electroosmotically drive fluid into the nucleus pulposus.
2. The apparatus according to claim 1 , wherein the support structure comprises a wire, and wherein the one or more intra-pulposus exposed electrode surfaces are defined by one or more non-insulated portions of the wire.
3. The apparatus according to claim 2 , wherein the wire has a diameter of no more than 200 microns.
4. The apparatus according to claim 1 , wherein the support structure is configured to be shaped as the complete ring that surrounds an area of at least 1 cm2 upon implantation.
5. The apparatus according to claim 1 , wherein the support structure is configured to be shaped as the partial ring that surrounds an area of at least 1 cm2 upon implantation.
6. The apparatus according to claim 1 , wherein the one or more intra-pulposus exposed electrode surfaces comprise at least two intra-pulposus exposed electrode surfaces, which are disposed along the support structure.
7. A method of treating an intervertebral disc of a subject, comprising:
implanting, within a nucleus pulposus of the disc, a support structure along which one or more intra-pulposus exposed electrode surfaces are disposed, such that the support structure is shaped as a partial ring or a complete ring after the implanting;
implanting one or more extra-pulposus exposed electrode surfaces outside the nucleus pulposus, in electrical communication with the disc; and
activating control circuitry to:
configure the intra-pulposus exposed electrode surfaces to be cathodes, and the one or more extra-pulposus exposed electrode surfaces to be one or more anodes, and,
drive the intra-pulposus exposed electrode surfaces and the one or more extra-pulposus exposed electrode surfaces to electroosmotically drive fluid into the nucleus pulposus to increase pressure in the disc.
8. The method according to claim 7 , wherein the support structure includes a wire, and wherein the one or more intra-pulposus exposed electrode surfaces are defined by one or more non-insulated portions of the wire.
9. The method according to claim 8 , wherein the wire has a diameter of no more than 200 microns.
10. The method according to claim 7 ,
wherein the disc defines a geometric center line segment perpendicular to a transverse plane of the disc, and
wherein implanting the support structure comprises implanting the support structure such that the support structure surrounds at least 180 degrees of the geometric center line segment.
11. The method according to claim 10 , wherein implanting the support structure comprises implanting the support structure such that the support structure surrounds at least 270 degrees of the geometric center line segment.
12. The method according to claim 7 , wherein implanting the support structure comprises implanting the support structure such that the support structure is shaped as the complete ring that surrounds an area of at least 1 cm2.
13. The method according to claim 7 , wherein implanting the support structure comprises implanting the support structure such that the support structure is shaped as the complete ring that surrounds an area equal to at least 15% of a greatest area of the nucleus pulposus measured in a transverse plane of the disc.
14. The method according to claim 7 , wherein implanting the support structure comprises implanting the support structure such that the support structure is shaped as the partial ring that surrounds an area of at least 1 cm2.
15. The method according to claim 7 , wherein implanting the support structure comprises implanting the support structure such that the support structure is shaped as the partial ring that surrounds an area equal to at least 15% of a greatest area of the nucleus pulposus measured in a transverse plane of the disc.
16. The method according to claim 7 , wherein the one or more intra-pulposus exposed electrode surfaces include at least two intra-pulposus exposed electrode surfaces, which are disposed along the support structure.