Granted Patent
B2
US 11,834,416 · App. 16/698,332 · Granted Dec 5, 2023
Cleavable agents
Inventors:
Boyd M. Goodson (Carbondale, IL); Eduard Y. Chekmenev (Troy, MI); Bryce E. Kidd (Carbondale, IL); Jamil A. Mashni (Carbondale, IL); Miranda Limbach (Creal Springs, IL); Yuqing Hou (Carbondale, IL); Fan Shi (Houston, TX)
C07D233/60B01J31/12C07D213/46C07D213/63C07D241/12C07D401/06C07F9/6506G01R33/282B01J2531/827G01R33/46
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Abstract
The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
Claims (1)
1. A cleavable agent selected from the group consisting of 1- 13 C- 15 N 2 -acetylimidazole and 1- 13 C- 15 N 2 -pyruvyl-imidazole.
Assignments (4)
CONFIRMATORY LICENSE
Recorded Mar 26, 2025
From: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 070631/0617 →
CONFIRMATORY LICENSE
Recorded Nov 6, 2023
From: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
To: UNITED STATES GOVERNMENT
Reel/Frame 065472/0798 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 29, 2020
From: CHEKMENEV, EDUARD Y
To: VANDERBILT UNIVERSITY
Reel/Frame 052528/0553 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 29, 2020
From: GOODSON, BOYD M.; KIDD, BRYCE E.; MASHNI, JAMIL A.; LIMBACH, MIRANDA; HOU, YUQING; SHI, FAN
To: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
Reel/Frame 052528/0612 →
Continuity (2)
Provisional Application
62772902
· Nov 29, 2018