Dexamethasone prodrug compositions and uses thereof
The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.
1. A compound having the structure:
2. A method of treating an inflammatory disease or disorder in a subject in need thereof, the method comprising administering to the subject the compound of claim 1 in an amount sufficient to treat the inflammatory disease or disorder in the subject.
3. The method of claim 2 , wherein the compound is administered locally.
4. The method of claim 3 , wherein the compound is administered intraocularly.
5. The method of claim 3 , wherein the compound is administered into a joint space.
6. The method of claim 2 , wherein the inflammatory disease or disorder is osteoarthritis.
7. The method of claim 2 , wherein the compound is administered to a location by coating a surface of an implantable medical device with the compound and implanting the medical device into the location.
8. An article comprising the compound of claim 1 , wherein the article provides controlled release of dexamethasone at 37° C. in phosphate buffered saline.
9. The article of claim 8 , wherein at least 70% (w/w) of the article is Compound 1.
10. The article of claim 9 , wherein at least 90% (w/w) of the article is Compound 1.
11. The article of claim 8 , wherein the article is a fiber, fiber mesh, woven fabric, non-woven fabric, pellet, cylinder, hollow tube, microparticle, nanoparticle, or shaped article.
12. A method of treating an inflammatory disease or disorder in a subject in need thereof, the method comprising administering to the subject the article of claim 8 in an amount sufficient to treat the inflammatory disease or disorder in the subject.
13. The method of claim 12 , wherein the article is administered locally.
14. The method of claim 13 , wherein the article is administered intraocularly.
15. The method of claim 13 , wherein the article is administered into a joint space.
16. The method of claim 12 , wherein the article is a fiber, fiber mesh, woven fabric, non-woven fabric, pellet, cylinder, hollow tube, microparticle, nanoparticle, or shaped article.
17. The method of claim 12 , wherein at least 70% (w/w) of the article is Compound 1.
18. The method of claim 12 , wherein at least 90% (w/w) of the article is Compound 1.
19. The method of claim 12 , wherein the inflammatory disease or disorder is osteoarthritis.