Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity
A tumescent composition comprising a drug or a therapeutic agent in a tumescent solution, wherein a tumescent concentration of the drug or therapeutic agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic, wherein the tumescent solution does not comprise an antibiotic.
1. A tumescent composition comprising a glucocorticoid drug as an anti-inflammatory drug dissolved in a tumescent solution, wherein:
(a) a tumescent concentration of the glucocorticoid drug is simultaneously:
1) below a threshold for local, subcutaneous tissue toxicity,
2) above a threshold for positive local therapeutic effect, and
3) above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and
(b) the tumescent solution comprises:
(i) a vasoconstrictor; and
(ii) a pharmaceutically acceptable carrier.
2. The tumescent composition of claim 1 , wherein said vasoconstrictor comprises epinephrine.
3. The tumescent composition of claim 2 wherein the concentration of epinephrine is approximately 0.2 to 1.5 mg/L.
4. The tumescent composition of claim 1 , wherein said glucocorticoid drug reduces neuropathic pain or the risk of developing neuropathic pain.
5. The tumescent composition according to claim 1 , wherein the glucocorticoid drug is selected from the group consisting of triamcinolone, dexamethsasone, prednisolone, methylprednisolone, budesonide betamethasone, hydrocortisone and cortisone.
6. A method of subcutaneous delivery of a glucocorticoid drug to a subject comprising administering to said subject the tumescent composition according to claim 1 .
7. The method of claim 6 , wherein infiltration of the tumescent composition achieves both prolonged local concentration of the glucocorticoid drug within a tumescent subcutaneous tissue as well as a prolonged slow constant systemic absorption of glucocorticoid drug from the tumescent tissue into a systemic circulation.
8. The method of claim 6 , wherein a pharmacokinetic profile of the systemic absorption resembles a slow, constant, intravenous (IV) infusion.
9. The method of claim 6 , wherein the subcutaneous concentration of the glucocorticoid drug achieved is from about 1-100 times the maximum subcutaneous interstitial fluid concentration that can be achieved by conventional IV, IM or oral delivery of the glucocorticoid drug.
10. The method of claim 6 , wherein local and systemic blood viscosity are reduced in the subject and local and systemic oxygenation of tissues in the subject is increased.
11. The method of claim 6 , wherein said tumescent composition reduces neuropathic pain or the risk of developing neuropathic pain.
12. The method of claim 11 , wherein said neuropathic pain is selected from the group consisting of postherpetic neuralgia, trigeminal neuralgia, phantom limb pain, diabetic neuropathy, carpal tunnel syndrome, sciatica, degenerative disk disease, spinal cord injury, post-surgical pain and cancer.
13. The method of claim 6 , wherein the tumescent composition further comprises a chemotherapy agent, wherein the method treats a localized cancer.
14. The method of claim 13 , wherein the localized cancer is selected from the group consisting of skin cancer, breast cancer, lymphoma, Pancreatic Adenocarcinoma, Insulinoma, lung cancer, colon cancer, prostate cancer, ovarian cancer and a metastatic cancer.
15. The method of claim 14 , wherein said skin cancer is selected from the group consisting of Basal Cell Carcinoma, Squamous Cell Carcinoma, melanoma, Merkel Cell Carcinoma and Kaposi's Sarcoma.
16. A method of treating or preventing sepsis or Systemic Inflammatory Response Syndrome (SIRS) in a subject comprising:
(a) identifying a subject suffering from or at risk of sepsis or SIRS; and
(b) administering to said subject a tumescent composition according to claim 1 ,
wherein the tumescent composition acts as a reservoir for the glucocorticoid drug, simultaneously providing a sustained high local interstitial drug concentration and a sustained systemic concentration of the glucocorticoid drug resembling a slow constant IV infusion in the subject, thereby effectively treating or preventing sepsis or SIRS in the subject.
17. A method of reducing a risk of surgical site infection in a patient during a medical procedure comprising administering by tumescent delivery to a subcutaneous compartment in the patient a tumescent composition according to claim 1 .