Substituted tetrahydroquinolinone compounds as ROR gamma modulators

1. A compound of formula (I):

or a pharmaceutically acceptable salt or a stereoisomer thereof;

wherein,

ring Het is heterocyclyl;

each Y 1 , Y 2 and Y 3 are independently CR a or N, wherein 0-2 of Y 1 , Y 2 and Y 3 are N;

each Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are independently CR a or N, wherein 0-3 of Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are N;

L is *—NR b —C(O)—(CR b R c ) n —, *—C(O)—NR b —(CR b R c ) n —, *—NR b —S(O) 2 —(CR b R c ) n — or *—S(O) 2 —NR b —(CR b R c ) n —; wherein the group marked with * is connected to the ring containing Y 1 , Y 2 and Y 3 ;

each R 1 , R 2 , R 6 and R 7 are independently hydrogen, halo, alkyl, hydroxy, hydroxyalkyl, cyano, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, —COR d or —COOR d ;

R 3 at each occurrence is independently hydroxy, halo, alkyl, alkylamino, alkoxy, haloalkyl, haloalkoxy or cycloalkyl; alternatively, two R 3 on the same carbon together form an oxo (═O) group;

R 4 is hydrogen, alkyl or alkoxy;

R 5 is alkyl, —(CH 2 ) n NR b R c , hydroxyalkyl, cycloalkyl, aryl or heterocyclyl;

R a is hydrogen, alkyl, alkoxy, halo, cycloalkyl or aryl;

R b and R c are each independently hydrogen, alkyl or alkoxyalkyl;

alternatively, R b and R c on the same atom together form a ring;

R d is hydrogen, alkyl, alkoxy or cycloalkyl;

m is 0 to 3; and

n is 0 to 3.

2. The compound of claim 1 , wherein the compound is of formula (IA):

or a pharmaceutically acceptable salt or a stereoisomer thereof.

3. The compound of claim 1 , wherein the compound is of formula (ID):

or a pharmaceutically acceptable salt or a stereoisomer thereof.

4. The compound of claim 1 , wherein the compound is of formula (IE):

or a pharmaceutically acceptable salt or a stereoisomer thereof.

5. The compound of claim 3 , wherein L is *—CONHCH 2 — wherein the group marked with * is connected to the ring containing Y 1 , Y 2 and Y 3 .

6. The compound of claim 5 , wherein R 1 and R 2 are each hydrogen.

7. The compound of claim 5 , wherein R 4 is alkyl.

8. The compound of claim 7 , wherein R 4 is methyl.

9. The compound of claim 5 , wherein R 3 at each occurrence is alkyl.

10. The compound of claim 5 , wherein R 5 is alkyl.

11. The compound of claim 10 , wherein R 5 is ethyl.

12. The compound of claim 5 , wherein each Y 1 , Y 2 and Y 3 are independently CR a or N, wherein R a is hydrogen and 0-2 of Y 1 , Y 2 and Y 3 are N.

13. The compound of claim 5 , wherein each Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are independently CR a or N, wherein R a is hydrogen and 0-3 of Z 1 , Z 2 , Z 3 , Z 4 and Z 5 are N.

14. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof; wherein ring Het is pyridyl, pyridazinyl, pyridazinone, pyrimidinyl, pyrazinyl, pyrazolyl, imidazopyrazinyl, imidazopyridyl, pyrrolopyrazinyl, thienyl, benzodioxolyl, benzimidazolyl, imidazolyl, imidazopyridazinyl or tetrahydroisoquinolinonyl.

15. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein,

16. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein

17. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein L is *—NHCOCH 2 — or *CONHCH 2 — wherein the group marked with * is connected to the ring containing Y 1 , Y 2 and Y 3 .

18. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein each of R 1 , R 2 , R 6 and R 7 are each hydrogen; and R 4 is alkyl.

19. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein R 5 is alkyl.

20. The compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof wherein R a is hydrogen or alkyl.

21. A compound, selected from among:

Compound

No.

IUPAC Name

1

N-(4,6-dimethyl-5-oxo-6-(pyridin-2-yl)-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-

(ethylsulfonyl)phenyl)acetamide;

2

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-3-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

3

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(6-(trifluoromethyl)pyridin-3-

yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

4

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridin-2-yl)-7,7-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

5

2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyridin-2-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

6

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

7

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

8

N-(6-methyl-5-oxo-6-(5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

9

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

10

N-(6-(5-chloropyridin-2-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-

(4-(methylsulfonyl)phenyl)acetamide;

11

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-3,6-dimethyl-5-

oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

12

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

13

N-(6-(imidazo[1,2-a]pyridin-8-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

14

N-(6-ethyl-6-(imidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

15

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(pyrrolo[1,2-a]pyrazin-l-yl)-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

16

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

17

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

18

N-(4,6-dimethyl-5-oxo-6-(pyridin-3-yl)-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-

(ethylsulfonyl)phenyl)acetamide;

19

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

20

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

21

2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

22

2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

23

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoropyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

24

N-(6-(5-chloro-3-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

25

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxypyrimidin-5-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

26

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-4,6-dimethyl-5-

oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

27

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrazin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

28

N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

29

N-(6-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

30

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxypyrimidin-4-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

31

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

32

N-(4,6-dimethyl-5-oxo-6-(5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

33

N-(6-(imidazo[1,2-a]pyrazin-8-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

34

N-(4,6-dimethyl-6-(6-methylpyridazin-3-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

35

N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-

2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

36

2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-hydroxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

37

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxypyridin-4-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

38

N-(6-(5-chloro-3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

39

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

40

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-hydroxypyridin-3-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

41

N-(6-(6-ethylpyridazin-3-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-

(4-(ethylsulfonyl)phenyl)acetamide;

42

N-(6-(benzo[d][1,3]dioxol-5-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

43

N-(4,6-dimethyl-6-(1-methyl-1H-benzo[d]imidazol-5-yl)-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

44

N-(4,6-dimethyl-6-(2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

45

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(5-methylthiophen-2-yl)-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

46

N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-

2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

47

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(1H-pyrazol-1-yl)-5,6,7,8-

tetrahydroquinolin-2-yl)acetamide;

48

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-6,8-dimethyl-5-

oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

49

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

50

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-isopropylpyrimidin-4-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

51

N-(6-(2,6-dimethylimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

52

N-(4,6-dimethyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

53

N-(4,6-dimethyl-5-oxo-6-(6-(trifluoromethyl)pyridazin-3-yl)-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

54

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-7-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

55

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(6-(trifluoromethyl)pyridazin-

3-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

56

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

57

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-isopropoxypyridazin-3-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

58

2-(4-(ethylsulfonyl)-2-fluorophenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-

a]pyrazin-8-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

59

N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

60

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-isopropylpyrazin-2-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

61

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

62

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-isopropylpyridazin-3-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

63

N-(6-(6-ethylpyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

64

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

65

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

66

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-

6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

67

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methyl-6-(trifluoromethyl)-

pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

68

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(5-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

69

N-(6-(2,6-dimethylpyrimidin-4-yl)-7,7-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

70

N-(4,6-dimethyl-6-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

71

N-(6-(3-cyclopropylimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

72

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(2-(trifluoromethyl)-

imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

73

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

74

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-(trifluoromethyl)-

imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

75

N-(4,6-dimethyl-6-(2-methylimidazo[1,2-b]pyridazin-6-yl)-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

76

N-(6-(5-cyclopropyl-6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

77

2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-b]pyridazin-6-yl)-4,6-dimethyl-5-

oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

78

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methyl-2-(trifluoromethyl)-

pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

79

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide;

80

2-(5-(ethylsulfonyl)pyridin-2-yl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-

oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

81

N-(6-(2,6-dimethylpyrimidin-4-yl)-6,7-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

82

N-(6-(2,6-dimethylpyrimidin-4-yl)-7-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

84

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxypyridin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

85

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

86

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxy-4-methylpyridin-3-yl)-4,6-dimethyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

87

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-7,7-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

88

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

89

N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(methylsulfonyl)phenyl)acetamide;

90

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-hydroxypyridin-2-yl)-7,7-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

91

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-7-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

92

N-(6-(5-chloroimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

93

N-(6-(6-chloropyridazin-3-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-

(4-(ethylsulfonyl)phenyl)acetamide;

94

3-(2-(2-(4-(ethylsulfonyl)phenyl)acetamido)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-6-yl)-6-methoxypyridazine 1-oxide;

95

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-4-methylpyridazin-3-yl)-4,6-

dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

96

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-5-methylpyridazin-3-yl)-4,6-

dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

97

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoroimidazo[1,2-a]pyrazin-8-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

98

N-(6-(6-(dimethylamino)pyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

99

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinoline-2-carboxamide;

100

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydronaphthalen-

2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

101

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-85);

102

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-85);

103

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide; (Isomer-1 of Compound-7);

104

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide; (Isomer-2 of Compound-7);

105

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-9);

106

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-9);

107

N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide; (Isomer-1 of

Compound-28);

108

N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide; (Isomer-2 of

Compound-28);

109

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-31);

110

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-31);

111

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-56);

112

2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-56);

113

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-49);

114

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-49);

115

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-65);

116

2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-65);

117

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-16);

118

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-16);

119

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-1 of Compound-64);

120

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-

5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide; (Isomer-2 of Compound-64);

121

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-

(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-

yl)acetamide; (Isomer-1 of Compound-74);

122

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-

(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-

yl)acetamide; (Isomer-2 of Compound-74);

123

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide; (Isomer-1 of Compound-79);

124

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide; (Isomer-2 of Compound-79);

125

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinoline-2-carboxamide; (Isomer-1 of Compound-99);

126

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-

5,6,7,8-tetrahydroquinoline-2-carboxamide; (Isomer-2 of Compound-99);

129

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-

6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

130

2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-

6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

131

N-(6-(6-ethyl-2-methylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

132

N-(6-(2-ethyl-6-methylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-

tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

133

N-(6-(2,6-diethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

135

2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-4,6-

dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

136

N-(7-(2,6-dimethylpyrimidin-4-yl)-7-methyl-8-oxo-5,6,7,8-tetrahydroquinolin-3-

yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

137

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-

2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

138

N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoxalin-

2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;

139

2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methyl-6-(trifluoromethoxy)-

pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;

140

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-7-isopropyl-5-oxo-

5,6,7,8-tetrahydroquinoline-2-carboxamide;

141

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-8-isopropyl-5-oxo-

5,6,7,8-tetrahydroquinoline-2-carboxamide; and

142

6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-7-isopropyl-6-

methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

22. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt or a stereoisomer thereof and a pharmaceutically acceptable carrier or excipient.

23. The compound of claim 21 having the structure:

or a pharmaceutically acceptable salt thereof or a stereoisomer thereof.

24. The compound of claim 23 , which is N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethyl sulfonyl)phenyl)acetamide or an enantiomer thereof.

25. The compound of claim 23 , which is N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethyl sulfonyl)phenyl)acetamide or a pharmaceutically acceptable salt thereof.

26. The compound of claim 23 , which is the (S)-enantiomer of N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide or a pharmaceutically acceptable salt thereof.

27. The compound of claim 23 , which is the (R)-enantiomer of N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide or a pharmaceutically acceptable salt thereof.

28. A pharmaceutical composition comprising a compound of claim 23 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.

29. The compound of claim 25 having the structure:

or a pharmaceutically acceptable salt or a stereoisomer thereof.

30. The compound of claim 29 , which is 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethyl sulfonyl)benzyl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide or an enantiomer thereof.

31. The compound of claim 29 , which is 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide or a pharmaceutically acceptable salt thereof.

32. The compound of claim 29 , which is the (S)-enantiomer of 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide or a pharmaceutically acceptable salt thereof.

33. The compound of claim 29 , which is the (R)-enantiomer of 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide or a pharmaceutically acceptable salt thereof.

34. A pharmaceutical composition comprising a compound of claim 29 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.

35. A compound, having the structure:

or a pharmaceutically acceptable salt or an enantiomer thereof.

36. A method of treating a disorder or disease mediated by RORγ in a subject in need thereof comprising administering to the subject a compound of claim 1 , wherein the disorder or disease mediated by RORγ is an immune disorder or an inflammatory disease.

37. The method according to claim 36 , wherein the disease or disorder is rheumatoid arthritis, psoriasis, chronic graft-versus-host disease, acute graft-versus-host disease, Crohn's disease, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, Celiac Sprue, idiopathic thrombocytopenic thrombotic purpura, myasthenia gravis, Sjogren's syndrome, asthma, epidermal hyperplasia, scleroderma or ulcerative colitis.

38. The method according to claim 37 , wherein the disease or disorder is psoriasis.

39. The method of claim 36 , further comprising administering to the subject a second therapeutic agent.

40. A method of reducing an amount of IL-17 in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .

41. The method of claim 36 , wherein the subject is a human or other mammal.