IP Library › Granted Patent US 11,096,692
Granted Patent B2
US 11,096,692 · App. 16/714,611 · Granted Aug 24, 2021

Blood oxygenation treatment methods and devices

Inventors: Stanton J. Rowe (Newport Coast, CA); Robert S. Schwartz (Inver Grove Heights, MN); Glen Rabito (Lake Forest, CA); Robert C. Taft (Orange, CA); Elliot Howard (Irvine, CA); Alexander Siegel (Aliso Viejo, CA); Joseph Passman (Costa Mesa, CA)
Assignee: NXT Biomedical, LLC
A61B17/11A61B5/14542A61B5/686A61B17/00234A61B17/12022A61B2017/00252A61B2017/1139
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Quick Facts
Patent No.
US 11,096,692
App. No.
16/714,611
Granted
Aug 24, 2021
Kind
B2
Abstract

Methods and devices for increasing oxygenation levels in the blood supply and thereby treating the condition of hypoxemia. Multiple approaches such as pressure reduction in the pulmonary circulatory system, reducing triggering mechanisms in the main pulmonary artery and restricting flow in the pulmonary circulatory system are disclosed. Interventions associated with those approaches can including shunting, restrictors, compliance devices, pharmacologic substances, etc.

Claims (46)

1. A method of treating hypoxemia in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

said intervening comprising reducing pressure in a pulmonary system of said patient through right-to-right shunting of blood chambers or vessels;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention.

2. A method according to claim 1 , wherein said right-to-right shunting comprises shunting flow from the right pulmonary artery to the superior vena cava.

3. A method according to claim 1 , wherein a combination of two or more interventions are performed.

4. A method according to claim 1 , further comprising iterating said intervening based on the comparing of said post-intervention oxygen measurement with said baseline oxygen measurement.

5. A method according to claim 4 , wherein the iterating of said intervening is repeated until target oxygen measurement is obtained.

6. A system for treating hypoxemia in a patient comprising:

a device for measuring oxygen levels in a patient;

a device for intervening invasively in the native pulmonary oxygenation process of a patient, said device comprising a shunting device, wherein said shunting device is an implantable shunt and configured for right-to-right shunting;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient.

7. A system according to claim 6 , wherein said implantable shunt is configured for placement in the right pulmonary artery and the superior vena cava of said patient.

8. A method of treating hypoxemia in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

said intervening comprising restricting flow in a pulmonary system of said patient through placing a flow restriction element into the main pulmonary artery of said patient;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention.

9. A method of treating hypoxemia in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

said intervening comprising reducing pressure in a pulmonary circulation by introducing compliance into said pulmonary circulation by placing a gas-filled balloon into the pulmonary circulation;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention.

10. A method according to claim 9 , wherein said balloon is disposed in the SVC.

11. A method of treating hypoxemia in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

said intervening comprising reducing pressure in a pulmonary circulation by draining the lymphatic system; wherein draining the lymphatic system includes draining the interstitial spaces of said lymphatic system;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention.

12. A system for treating hypoxemia in a patient comprising:

a device for measuring oxygen levels in a patient;

a device for intervening invasively in the native pulmonary oxygenation process of a patient, said device comprising a flow restriction element configured for placement into the main pulmonary artery of said patient;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient.

13. A system for treating hypoxemia in a patient comprising:

a device for measuring oxygen levels in a patient;

a device for intervening invasively in the native pulmonary oxygenation process of a patient, said device comprising a compliance device in the form of a gas-filled balloon configured for placement in the pulmonary circulation;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient.

14. A system for treating hypoxemia in a patient comprising:

a device for measuring oxygen levels in a patient;

a device for intervening invasively in the native pulmonary oxygenation process of a patient, said device comprising a lymphatic drainage device configured to drain the interstitial spaces of said lymphatic system;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2026
From: NXT BIOMEDICAL, LLC
To: EDWARDS LIFESCIENCES CORPORATION
Reel/Frame 074374/0978 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 052043 FRAME: 0428. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Apr 22, 2021
From: ROWE, STANTON J.; SCHWARTZ, ROBERT S.; RABITO, GLEN; TAFT, ROBERT C.; HOWARD, ELLIOT; SIEGEL, ALEXANDER; PASSMAN, JOSEPH
To: NXT BIOMEDICAL, LLC
Reel/Frame 056009/0275 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 6, 2020
From: ROWE, STANTON J.; SCHWARTZ, ROBERT S.; RABITO, GLEN; TAFT, ROBERT C.; HOWARD, ELLIOT; SIEGEL, ALEXANDER; PASSMAN, JOSEPH
To: NXT BIOMEDICAL
Reel/Frame 052043/0428 →
Continuity (5)
Provisional Application 62779380 · Dec 13, 2018
Provisional Application 62802656 · Feb 7, 2019
Provisional Application 62896144 · Sep 5, 2019
Provisional Application 62942631 · Dec 2, 2019
Related Publication 20200187945A1 · Jun 18, 2020
Cited By (1)
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