Carousel for modular biologic production units
An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.
1. An automated carousel comprising:
a substantially vertical track assembly comprising an upright drive track and a support track;
a plurality of translation assemblies, wherein each of the plurality of translation assemblies is a hub assembly having a first end defining a coupling for an input shaft of a biological production unit in a cantilevered orientation, and
a central hub comprising:
an inner hub configured to axially rotate the biological production unit; and
a resistance arm having a pivotally connected support carriage cooperatively engaged with the support track for translational movement thereon;
wherein each translation assembly supports a biological production unit in a cantilevered orientation, said plurality of translation assemblies configured to provide: (i) separate translational movement of each biological production unit along the drive track and the support track, while maintaining the cantilevered orientation of each biological production unit stable with respect to gravity, and separately, (ii) axial rotation of each biological production unit.
2. The automated carousel of claim 1 , wherein the central hub further includes an outer hub shell supporting a drive carriage for cooperatively engaging with the drive track for translational movement thereon.
3. The automated carousel of claim 1 , wherein the inner hub comprises a motor driven central shaft for engaging with the input shaft of the biological production unit, wherein actuation of the motor actively rotates the central shaft at a controlled speed causing axial rotation of the associated biological production unit.
4. The automated carousel of claim 2 , wherein the drive carriage comprises a drive block assembly with one face thereof comprising affixed vertically arranged pairs of outwardly projecting bearing members for gripping the drive track and for engaging with a drive belt or a drive linkage adapted to move along the course of travel defined by the drive track.
5. The automated carousel of claim 1 , wherein the support carriage comprises a support block assembly with one face thereof comprising affixed vertically arranged pairs of outwardly projecting bearing members for gripping the support track and for engaging with a drive belt or a drive linkage adapted to move along the course of travel defined by the support track.
6. The automated carousel of claim 1 , wherein a second end of the hub assembly comprises a port for entry of a connector for centrally provided operational resources to the biological production unit.
7. The automated carousel of claim 6 , wherein said port leads to a hollow shaft extending through the central hub to the biological production unit.
8. The automated carousel of claim 7 , wherein the connector comprises cabling enclosing separate operational resources, the cabling originating from a central source and connecting each successive biological production unit on said carousel.
9. The automated carousel of claim 8 , wherein the operational resources are electrical supply lines, gas supply lines and controller connections.
10. The automated carousel of claim 1 , wherein said biological production unit is a cell and/or tissue engineering system configured to perform one or more of: sterile reception/storage of tissue biopsy; automated monitoring of digestion process; digestion of biopsy tissue to yield disassociated cells; cell sorting and selection; safe waste collection; cell seeding on or within a proliferation substrate; scaffold proliferation of cells to expand cell populations; cell washing and cell collection; cell seeding on or within a tissue engineering scaffold or matrix; cell differentiation to allow specialization of cellular activity; tissue formation; mechanical and/or biochemical stimulation to promote tissue maturity; harvest of tissue engineered constructs/implants for reconstructive surgery; and storage and transportation of cells and implantable tissue.
11. The automated carousel of claim 1 , wherein the translational movement of each biological production unit along the drive track and support track, and separately, the axial rotation of each biological production unit, allow for ergonomic access to each biological production unit by a user.
12. An automated carousel system for the distribution and ergonomic positioning of multiple biological production units, each of the biological production units comprising an automated individually operable cell and/or tissue engineering system, the automated carousel system comprising:
an automated carousel comprising:
a substantially vertical track assembly comprising a drive track and a support track vertically offset and spaced apart from one another; and
a plurality of translation assemblies connecting the drive track and the support track at spaced apart positions, wherein each of the plurality of translation assemblies is a hub assembly having a first end defining a coupling for an input shaft of the biological production unit in a cantilevered orientation, and a second end having a vertically downward extending resistance arm, and
a central hub comprising:
an inner hub comprising a central shaft for engaging with the input shaft of the biological production unit, the central shaft mounted to the vertically downward extending resistance arm of the second end, the inner hub configured to axially rotate the biological production unit; and
the vertically downward extending resistance arm having a pivotally connected support carriage cooperatively engaged with the support track for translational movement thereon;
each of said plurality of translation assemblies supporting each biological production unit in the cantilevered orientation, wherein said plurality of translation assemblies are configured to provide: (i) separate translational movement of each biological production unit along the connected drive track and support track while maintaining the cantilevered orientation of each biological production unit stable with respect to gravity, and separately, (ii) axial rotation of each biological production unit;
a controller for independent biological control of each cell and/or tissue engineering system within each of said biological production units;
a vertical housing assembly supporting the automated carousel, the housing assembly comprising a central source of operational resources;
a connector for interconnecting the central source of operational resources to each successive biological production unit; and
a computer connection.
13. The automated carousel system of claim 12 , wherein each biological production unit comprises a connected interface for communication by a user, said connected interface connected to the computer connection.
14. The automated carousel system of claim 12 , comprising up to 24 translation assemblies.
15. The automated carousel system of claim 12 , wherein the translational movement of each biological production unit along the connected drive track and support track, and separately, the axial rotation of each biological production unit, allow for ergonomic access to each biological production unit by a user.