Anti-HIV peptides
Simple β-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
1. A vector comprising a polynucleotide encoding a peptide comprising an amino acid sequence, wherein the amino acid sequence consists of the amino acid sequence of SEQ ID NO: 2.
2. The vector of claim 1 , wherein the amino acid sequence consists of the amino acid sequence of SEQ ID NO: 3.
3. The vector of claim 2 , wherein the amino acid sequence consists of the amino acid sequence of SEQ ID NO: 4.
4. The vector of claim 1 , wherein the amino acid sequence consists of 13 amino acid residues at position 4 to position 16 of the amino acid sequence selected from the group consisting of SEQ ID NOs: 8-9 and SEQ ID NOs: 15-22.
5. The vector of claim 1 , wherein the amino acids at positions 1 and 13 of SEQ ID NO: 2 are cysteines.