IP Library › Granted Patent US 12,233,036
Granted Patent B2
US 12,233,036 · App. 16/724,467 · Granted Feb 25, 2025

Inhibitors of autophagy and DCAR-1 as novel anthelmintic agents

Inventors: Kailiang Jia (Boca Raton, FL); Thomas Parker (Boca Raton, FL)
Assignee: Florida Atlantic University Board of Trustees
A61K31/192A61P33/10A61K45/06
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Quick Facts
Patent No.
US 12,233,036
App. No.
16/724,467
Granted
Feb 25, 2025
Kind
B2
Abstract

Methods and compositions for controlling parasitic nematodes and treating or preventing a parasitic nematode infection are described herein. The methods include the use of compositions containing an autophagy inhibitor and/or a DCAR-1 inhibitor as anthelmintic agents.

Claims (10)

1. An anthelmintic composition comprising an active agent and an excipient,

wherein the active agent consists of an autophagy inhibitor and a DCAR-1 inhibitor,

wherein the DCAR-1 inhibitor is dihydrocaffeic acid.

2. The anthelmintic composition of claim 1 , wherein the autophagy inhibitor is present in an amount of 1 to 1000 μg/ml and the DCAR-1 inhibitor is present in an amount of 1 to 1000 μg/ml.

3. The anthelmintic composition of claim 1 , wherein the excipient is a pharmaceutically acceptable excipient.

4. The anthelmintic composition of claim 1 , wherein the excipient is an agriculturally acceptable excipient.

5. An anthelmintic composition comprising an active agent and an excipient, wherein the active agent consists of dihydrocaffeic acid and an anthelmintic agent selected from the group consisting of autophinib, azithromycin, ARN5187, AS1842856, autophagy inhibitor VII, bafilomycin Al, (±)-Bay K8644, 3BDO, chloroquine, concanamycin A, CA-5f, daurisoline, DBeQ, E64d, DC661, EAD1, edaravone, 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, GMX1778, GW4064, hydroxychloroquine sulfate, IITZ-01, KU-55933, L-asparagine, leupeptin, liensinine, lucanthone, LY294002 hydrochloride, Lys0I trihydrochloride, Lys05, Mdivi-1, 3-methyladenine, MHY1485, ML240, MRT67307 dihydrochloride, MRT68601 hydrochloride, MRT68921 dihydrochloride, NMS873, nocodazole, paclitaxel, PD98059, pepstatin A, PFK15, PFK158, PHY34, PIK-III, rapamycin, ROC-325, SAR-405, SB202190, SB203580, SBI-0206965, SP600125, sinomenine, spautin 1, thapsigargin, ULK-101, U0126, vinblastine sulfate, wortmannin, and xanthohumol.

6. The anthelmintic composition of claim 5 , wherein the dihydrocaffeic acid is present in an amount of 1 to 1000 μg/ml.

7. The anthelmintic composition of claim 5 , wherein the excipient is a pharmaceutically acceptable excipient.

8. The anthelmintic composition of claim 5 , wherein the excipient is an agriculturally acceptable excipient.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 2, 2022
From: FLORIDA ATLANTIC UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061054/0627 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 23, 2019
From: JIA, KAILIANG; PARKER, THOMAS
To: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
Reel/Frame 051352/0564 →
Continuity (2)
Provisional Application 62808602 · Feb 21, 2019
Related Publication 20200268697A1 · Aug 27, 2020
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