IP Library Granted Patent US 10,744,124
Granted Patent B2
US 10,744,124 · App. 16/724,935 · Granted Aug 18, 2020

Human therapeutic agents

Inventors: Gene H. Zaid (Sterling, KS); Thomas W. Burgoyne (Lake Zurich, IL)
Assignee: Ankh Life Sciences Limited
A61K31/437A61K31/11A61K31/12A61K31/4375A61K45/06A61K47/10
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Quick Facts
Patent No.
US 10,744,124
App. No.
16/724,935
Granted
Aug 18, 2020
Kind
B2
Abstract

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.

Claims (20)

1. A method of treating a cancer patient comprising the step of administering to the patient an anti-cancer composition comprising the combination of at least one curcumin component comprising curcumin, at least one harmine component comprising harmine, and at least one isovanillin component comprising isovanillin, wherein said composition exhibits anti-cancer synergy, wherein said cancer is selected from the group consisting of lymphoma, ovarian cancer and breast cancer.

2. The method of claim 1 , wherein said curcumin, said harmine, and said isovanillin are each at least about 50% pure.

3. The method of claim 1 , said isovanillin being present in an amount greater than the amounts of the harmine and the curcumin.

4. The method of claim 1 , the ratio of said at least one curcumin component, said at least one harmine component, and said at least one isovanillin component being from about 0.1-5:0.1-5:0.1-25.

5. The method of claim 1 , wherein the isovanillin component(s) is/are be present at a level of from about 25-85% by weight, the harmine component(s) is/are present at a level of from about 7-50% by weight, and the curcumin component(s) is/are present at a level of from about 5-40% by weight, based upon the total weight of the three components taken as 100% by weight.

6. The method of claim 1 , said composition exhibiting anti-cancer synergy with lymphoma cancer cells, MO205.

7. The method of claim 1 , said composition exhibiting anti-cancer synergy with ovarian cancer cells, A1847.

8. The method of claim 1 , said composition exhibiting anti-cancer synergy with breast cancer cells, du4475.

9. The method of claim 1 , wherein said components are individually and independently in the form of esters, metal complexes, pharmaceutically acceptable salts, and mixtures thereof.

10. The method of claim 1 , said composition being in the form of liquids, gels, suspensions, solutions, solids, capsules, pills, or tablets.

11. The method of claim 1 , including the step of administering said composition by oral, rectal, nasal, ophthalmic, parenteral, cutaneous, subcutaneous, or intramuscular administration.

12. A method of inhibiting the growth of cancer cells comprising the step of contacting said cells with an anti-cancer composition comprising the combination of at least one curcumin component comprising curcumin, at least one harmine component comprising harmine, and at least one isovanillin component comprising isovanillin, wherein said composition exhibits anti-cancer synergy, wherein said cancer is selected from the group consisting of lymphoma, ovarian cancer and breast cancer.

13. The method of claim 12 , wherein said curcumin, said harmine, and said isovanillin are each at least about 50% pure.

14. The method of claim 12 , said isovanillin being present in an amount greater than the amounts of the harmine and the curcumin.

15. The method of claim 12 , the ratio of said at least one curcumin component, said at least one harmine component, and said at least one isovanillin component being from about 0.1-5:0.1-5:0.1-25.

16. The method of claim 12 , wherein the isovanillin component(s) is/are be present at a level of from about 25-85% by weight, the harmine component(s) is/are present at a level of from about 7-50% by weight, and the curcumin component(s) is/are present at a level of from about 5-40% by weight, based upon the total weight of the three components taken as 100% by weight.

17. The method of claim 12 , said composition exhibiting anti-cancer synergy with lymphoma cancer cells, MO205.

18. The method of claim 12 , said composition exhibiting anti-cancer synergy with ovarian cancer cells, A1847.

19. The method of claim 12 , said composition exhibiting anti-cancer synergy with breast cancer cells, du4475.

20. The method of claim 12 , wherein said components are individually and independently in the form of esters, metal complexes, pharmaceutically acceptable salts, and mixtures thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 23, 2019
From: IONS PHARMACEUTICAL S.A R. L.
To: ANKH LIFE SCIENCES LIMITED
Reel/Frame 051355/0647 →
Continuity (12)
Continuation 16541665 · Aug 15, 2019
Continuation 16213774 · Dec 7, 2018
Continuation 15826101 · Nov 29, 2017
Continuation 15337987 · Oct 28, 2016
Continuation PCTIB2016000723 · Apr 20, 2016
Continuation In Part PCTUS2015055968 · Oct 16, 2015
Continuation In Part 14721011 · May 26, 2015
Continuation In Part 14721011 · May 26, 2015
Provisional Application 62184051 · Jun 24, 2015
Provisional Application 62161090 · May 13, 2015
Provisional Application 62066686 · Oct 21, 2014
Related Publication 20200121654A1 · Apr 23, 2020