IP Library Granted Patent US 11,957,124
Granted Patent B2
US 11,957,124 · App. 16/725,464 · Granted Apr 16, 2024

Organ perfusion systems

Inventors: Stuart Brian William Kay (Cambridge, GB); David George Robinson (Cambridge, GB); Philip David Canner (Cambridge, GB); Peter Alan Salkus (Cambridge, GB); Leslie James Russell (Oxford, GB); Peter John Friend (Oxford, GB); Constantin C. Coussios (Oxford, GB)
Assignee: ORGANOX LIMITED
A01N1/0247A01N1/021Y10T83/04
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Quick Facts
Patent No.
US 11,957,124
App. No.
16/725,464
Granted
Apr 16, 2024
Kind
B2
Abstract

A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.

Claims (32)

1. An organ perfusion system comprising:

a perfusion circuit configured for circulating perfusion fluid through the organ;

an excreted fluid collection sump configured for collecting fluid excreted by the organ;

an excreted fluid measurement system configured to measure, at each of a plurality of measurement times during perfusion of the organ, a respective flow rate of the excreted fluid produced by the organ; and

a controller having a memory and configured to store the measurement times and the respective flow rates as flow rate information in the memory; wherein the excreted fluid measurement system comprises an excreted fluid collection volume and a sensor arranged to detect when a predetermined volume of the excreted fluid has collected in the collection volume, and the controller is configured to remove the excreted fluid from the collection volume in response to said predetermined volume being reached, to determine a plurality of times between subsequent occurrences of the predetermined volume being reached, and from each of the plurality of times between subsequent occurrences of the predetermined volume being reached, to determine said respective flow rate of the excreted fluid from the organ.

2. A system as claimed in claim 1 further comprising an excreted fluid inlet, connected to the excreted fluid measurement system, and configured for cannulation to the organ.

3. A system as claimed in claim 1 further comprising a sling for supporting the organ; and

a leaked fluid sump located below the sling for collecting leaked fluid which has leaked from the organ.

4. A system as claimed in claim 3 further comprising a return duct connected to the leaked fluid sump and arranged to return leaked fluid from the sump to the perfusion circuit.

5. A system as claimed in claim 1 further comprising an outlet from the excreted fluid collection volume and a valve in the outlet, wherein the controller is configured to remove the excreted fluid from the collection volume by opening the valve.

6. A system as claimed in claim 1 wherein the controller is configured to record each occurrence of the predetermined volume being reached thereby to record a total volume of the excreted fluid flowing from the organ.

7. An organ perfusion system comprising:

a perfusion fluid supply duct for supplying perfusion fluid to the organ;

a fluid removal duct for removing perfusion fluid from the organ;

a surrogate organ removably connected between the perfusion fluid supply duct and the perfusion fluid removal duct so as to form a fluid circuit, so that perfusion fluid can be circulated in the circuit in preparation for connection of the organ,

a sling for supporting the organ;

a sump located below the sling for collecting leaked fluid which has leaked from the organ;

a return duct connected to the sump and arranged to return leaked fluid from the sump to the fluid circuit;

an excreted fluid collection sump for collecting waste fluid produced by the organ;

an excreted fluid measurement system configured to measure, at each of a plurality of measurement times during perfusion of the organ, a respective flow rate of the fluid excreted by the organ; and

a controller having a memory and configured to store the measurement times and the respective flow rates as flow rate information in the memory; wherein the excreted fluid measurement system comprises an excreted fluid collection volume and a sensor arranged to detect when a predetermined volume of the excreted fluid has collected in the collection volume, and the controller is configured to remove the excreted fluid from the collection volume in response to said predetermined volume being reached, to determine a plurality of times between subsequent occurrences of the predetermined volume being reached, and from each of the times between subsequent occurrences of the predetermined volume being reached, to determine said respective flow rate of the excreted fluid from the organ.

8. A method of perfusing an organ, the method comprising:

providing a perfusion circuit;

providing an excreted fluid collection volume and a sensor;

connecting the organ into the perfusion circuit;

circulating perfusion fluid through the perfusion circuit and the organ to perfuse the organ;

collecting excreted fluid which is excreted by the organ during the perfusion;

measuring for each of a plurality of times during perfusion of the organ, a respective rate of excretion of the excreted fluid; and

storing in memory each of the rates of excretion of the excreted fluid and the time at which it was measured, as flow rate information; wherein the measuring comprises detecting, using the sensor, when a predetermined volume of the excreted fluid has collected in the collection volume, removing the excreted fluid from the collection volume in response to said predetermined volume being reached and determining a plurality of times between subsequent occurrences of the predetermined volume being reached, and from each of the times between subsequent occurrences of the predetermined volume being reached, determining said respective flow rate of the excreted fluid from the organ.

9. A method as claimed in claim 8 further comprising displaying the flow rate information.

10. A method as claimed in claim 8 wherein the organ is a liver and the excreted fluid is bile.

11. A method as claimed in claim 8 wherein the organ is a kidney and the excreted fluid is urine.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2020
From: KAY, STUART BRIAN WILLIAM; ROBINSON, DAVID GEORGE; CANNER, PHILIP DAVID; SALKUS, PETER ALAN; RUSSELL, LESLIE JAMES; FRIEND, PETER JOHN; COUSSIOS, CONSTANTIN C.
To: ORGANOX LIMITED
Reel/Frame 051986/0887 →
Priority Claims (3)
GB 1119418 · Nov 10, 2011 · national
GB 1119419 · Nov 10, 2011 · national
WO PCT/GB2012/052782 · Nov 8, 2012 · international
Continuity (3)
Continuation 15338841 · Oct 31, 2016
Continuation 14357118
Related Publication 20200128813A1 · Apr 30, 2020