IP Library Granted Patent US 11,214,557
Granted Patent B2
US 11,214,557 · App. 16/739,642 · Granted Jan 4, 2022

MAGL inhibitors

Inventors: Cheryl A. Grice (Encinitas, CA); Daniel J. Buzard (San Diego, CA); Michael B. Shaghafi (San Diego, CA)
Assignee: H. LUNDBECK A/S
C07D295/185C07D213/55C07D241/12C07D263/32C07D305/06C07D305/08
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Quick Facts
Patent No.
US 11,214,557
App. No.
16/739,642
Granted
Jan 4, 2022
Kind
B2
Abstract

Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Claims (24)

1. A compound:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 :

3. A compound:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3 :

5. A compound:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 :

7. A compound:

or a pharmaceutically acceptable salt thereof.

8. The compound of claim 7 :

9. A compound:

or a pharmaceutically acceptable salt thereof.

10. The compound of claim 9 :

11. A compound:

or a pharmaceutically acceptable salt thereof.

12. The compound of claim 11 :

13. A compound:

or a pharmaceutically acceptable salt thereof.

14. The compound of claim 13 :

15. A compound:

or a pharmaceutically acceptable salt thereof.

16. The compound of claim 15 :

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE RECEIVING PARTY NAME PREVIOUSLY RECORDED AT REEL: 055679 FRAME: 0885. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 11, 2021
From: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
To: H. LUNDBECK A/S
Reel/Frame 056544/0697 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2021
From: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
To: H. LUNDBECK A/S.
Reel/Frame 055679/0885 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2020
From: GRICE, CHERYL A.; BUZARD, DANIEL J.; SHAGHAFI, MICHAEL B.
To: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
Reel/Frame 052713/0264 →
Continuity (3)
Continuation 16412212 · May 14, 2019
Provisional Application 62671985 · May 15, 2018
Related Publication 20200148653A1 · May 14, 2020