Stimulation configuration variation to control evoked temporal patterns

1. A method for programming an implantable medical device (IMD) having a plurality of electrodes implantable in a patient's spinal column, the method comprising:

selecting a stimulation program defining a plurality of sequential pulses, wherein each pulse comprises a first phase having a first polarity and a second phase having a second polarity opposite of the first polarity, wherein the first and second phases are separated by an inter-phase interval (IPI);

applying the stimulation program to the patient's spinal cord using a plurality of differing IPIs;

based on a determination of effectiveness of the stimulation program using the plurality of differing IPIs, determining a best IPI for addressing the patient's pain; and

using the best IPI in programming the IMD,

wherein the determination of effectiveness of the stimulation program using the plurality of differing IPIs is based on an electrospinogram (ESG) trace.

2. The method of claim 1 , wherein the determination of effectiveness of the stimulation program using the plurality of differing IPIs is based on patient feedback.

3. The method of claim 2 , wherein the patient feedback comprises rankings of the stimulation program using the plurality of differing IPIs.

4. The method of claim 1 , wherein the ESG trace is measured using one or more electrodes of the plurality of electrodes.

5. The method of claim 1 , wherein the determination of effectiveness of the stimulation program using the plurality of differing IPIs based on an ESG trace comprises comparing ESG traces obtained using the stimulation program with each of the differing IPIs to a target ESG trace.

6. The method of claim 5 , wherein the target ESG trace corresponds to stimulation settings that provide effective paresthesia coverage of the patient's pain.

7. The method of claim 5 , wherein the target ESG trace corresponds to settings that provide effective pain relief without paresthesia.

8. The method of claim 5 , further comprising obtaining a target ESG using supra-perception stimulation and wherein the determination of the effectiveness of the stimulation program using the one or more differing IPIs comprises using sub-perception stimulation.

9. The method of claim 5 , wherein the target ESG trace corresponds to stimulation that provides an effective temporal firing pattern of neural elements.

10. The method of claim 1 , further comprising determining the plurality of differing IPIs.

11. The method of claim 1 , wherein applying the stimulation program using the plurality of differing IPIs comprises using a graphical user interface (GUI) to select the plurality of differing IPIs.

12. The method of claim 11 , wherein the GUI is configured to provide a ranking of the effectiveness of the stimulation program using each of the plurality of differing IPIs.

13. The method of claim 11 , wherein the GUI is configured to provide an indication of an expected physiological and/or clinical effect associated with the stimulation program using the plurality of differing IPIs.

14. The method of claim 1 , wherein the second phase is actively driven.

15. The method of claim 1 , wherein the second phase is passively driven.

16. The method of claim 1 , wherein the plurality differing IPIs are from 10 microseconds to 500 microseconds.

17. The method of claim 1 , further comprising determining a best stimulation geometry to produce a desired physiological effect.