Milrinone controlled-release formulation
The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 μg/kg body weight/minute and 20 μg/kg body weight/minute.
1. An oral controlled-release formulation comprising:
(i) a core comprising:
(a) milrinone, or a pharmaceutically acceptable salt thereof;
(b) hydroxypropylmethylcellulose having a viscosity of 80,000 to 120,000 cps;
(c) hydroxypropylmethylcellulose having a viscosity of about 50 cps; and
(d) at least one pharmaceutically acceptable excipient; and
(ii) a sustained release coating;
wherein the formulation permits the release of milrinone or a pharmaceutically acceptable salt thereof, into the bloodstream in an amount that is effective to ameliorate symptoms of heart failure;
wherein the hydroxypropylmethylcellulose (80,000 to 120,000 cps) and the hydroxypropylmethylcellulose (about 50 cps) are in a ratio of about 1.5:1 to 1:1.5;
wherein the ratio of milrinone, or a pharmaceutically acceptable salt thereof, to total hydroxypropylmethylcellulose is about 1:3 to 1:5; and
wherein the formulation exhibits zero order release of about 100% of milrinone, or a pharmaceutically acceptable salt thereof, over about 12 hours at pH 6.8.
2. The formulation of claim 1 , wherein milrinone, or a pharmaceutically acceptable salt thereof, is present in an amount of 10-30% w/w of the core.
3. The formulation of claim 1 , wherein the ratio of hydroxypropylmethylcellulose (80,000 to 120,000 cps) to hydroxypropylmethylcellulose (50 cps) is about 1:1.
4. The formulation of claim 1 , wherein the ratio of milrinone, or a pharmaceutically acceptable salt thereof, to total hydroxypropylmethylcellulose is about 1:3.
5. The formulation of claim 1 , wherein the hydroxypropylmethylcellulose (80,000 to 120,000 cps) is present in an amount of 20-40% w/w of the core.
6. The formulation of claim 1 , wherein the hydroxypropylmethylcellulose (about 50 cps) is present in an amount of 20-40% w/w of the core.
7. The formulation of claim 1 , wherein the at least one pharmaceutically acceptable excipient is a binder, a lubricant, or a mixture thereof.
8. The formulation of claim 7 , wherein the binder is microcrystalline cellulose.
9. The formulation of claim 7 , wherein the binder is present in an amount of 16-30% w/w of the core.
10. The formulation of claim 1 , wherein the sustained-release coating comprises a cellulose derivative or a copolymer of acrylic acid, methacrylic acid and/or their esters.
11. The formulation of claim 10 , wherein the cellulose derivative is ethylcellulose.
12. The formulation of claim 11 , wherein the sustained-release coating further comprises a low viscosity hydroxypropylmethylcellulose.
13. The formulation of claim 1 , wherein the sustained-release coating comprises a copolymer of acrylic acid, acrylic ester, methacrylic acid, methacrylic ester or mixtures thereof, optionally with a methacrylic ester with quaternary ammonium groups.
14. The formulation of claim 1 , wherein the formulation comprises more than one sustained-release coating.
15. The formulation of claim 1 , further comprising one or more of a seal coating, a buffer coating, and an enteric coating.
16. The formulation of claim 1 , wherein the formulation further comprises an enteric coating.