IP Library Granted Patent US 11,084,810
Granted Patent B2
US 11,084,810 · App. 16/749,412 · Granted Aug 10, 2021

(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Inventors: Doris Riether (Biberach an der Riss, DE); Florian Paul Christian Binder (Maselheim, DE); Henri Doods (Warthausen, DE); Stephan Georg Mueller (Warthausen, DE); Janet Rachel Nicholson (Oberhoefen, DE); Achim Sauer (Ravensburg-Torkenweiler, DE)
Assignee: Centrexion Therapeutics Corporation
C07D417/12A61K31/422C07D261/04C07D261/14C07D413/02C07D413/12C07D413/14
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Quick Facts
Patent No.
US 11,084,810
App. No.
16/749,412
Granted
Aug 10, 2021
Kind
B2
Abstract

This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Claims (27)

1. A capsule containing

or a pharmaceutically acceptable salt thereof.

2. The capsule of claim 1 , wherein the capsule contains from 1 mg to 1000 mg of

or a pharmaceutically acceptable salt thereof.

3. The capsule of claim 1 , wherein the capsule contains from 25 mg to 500 mg of

or a pharmaceutically acceptable salt thereof.

4. The capsule of claim 1 , wherein the capsule contains

5. The capsule of claim 1 , wherein the capsule contains from 1 mg to 1000 mg of

6. The capsule of claim 1 , wherein the capsule contains from 25 mg to 500 mg of

7. A pill containing

or a pharmaceutically acceptable salt thereof.

8. The pill of claim 7 , wherein the pill contains from 1 mg to 1000 mg of

or a pharmaceutically acceptable salt thereof.

9. The pill of claim 7 , wherein the pill contains from 25 mg to 500 mg of

or a pharmaceutically acceptable salt thereof.

10. The pill of claim 7 , wherein the pill contains

11. The pill of claim 7 , wherein the pill contains from 1 mg to 1000 mg of

12. The pill of claim 7 , wherein the pill contains from 25 mg to 500 mg of

13. A tablet containing

or a pharmaceutically acceptable salt thereof.

14. The tablet of claim 13 , wherein the tablet contains from 1 mg to 1000 mg of

or a pharmaceutically acceptable salt thereof.

15. The tablet of claim 13 , wherein the tablet contains from 25 mg to 500 mg of

or a pharmaceutically acceptable salt thereof.

16. The tablet of claim 13 , wherein the tablet contains

17. The tablet of claim 13 , wherein the tablet contains from 1 mg to 1000 mg of

18. The tablet of claim 13 , wherein the tablet contains from 25 mg to 500 mg of

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Nov 21, 2025
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P., AS AGENT
To: CENTREXION THERAPEUTICS CORPORATION
Reel/Frame 073683/0099 →
SECURITY INTEREST Recorded Nov 21, 2025
From: CENTREXION THERAPEUTICS CORPORATION
To: ANKURA TRUST COMPANY, LLC, AS ADMINISTRATIVE AND COLLATERAL AGENT
Reel/Frame 073683/0108 →
SECURITY INTEREST Recorded Jul 12, 2023
From: CENTREXION THERAPEUTICS CORPORATION
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P., AS AGENT
Reel/Frame 064256/0125 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2020
From: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
To: CENTREXION THERAPEUTICS CORPORATION
Reel/Frame 051672/0258 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2020
From: RIETHER, DORIS; BINDER, FLORIAN PAUL CHRISTIAN; DOODS, HENRI; MUELLER, STEPHAN GEORG; NICHOLSON, JANET RACHEL; SAUER, ACHIM
To: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Reel/Frame 051758/0330 →
Priority Claims (1)
EP 13168165 · May 17, 2013 · regional
Continuity (4)
Continuation 16143523 · Sep 27, 2018
Continuation 15491035 · Apr 19, 2017
Continuation 14891051
Related Publication 20200262830A1 · Aug 20, 2020
Cited By (1)
US 12,344,601