Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections

1. A method of treatment and/or prevention of a bacterial vaginosis and/or a bacterial infection from a bacteria selected from the group consisting of Gardnerella vaginalis, Porphyromonas gingivalis, Escherichia coli, Pseudomonas aeruginosa, Acetinobacter baumanii, Streptococcus pyogenes , Beta-Hemolytic Streptococci Group C, Beta-Hemolytic Streptococci Group G, and/or Streptococcus agalactiae , said method consisting of administering to an individual in need thereof a pharmaceutical composition comprising a compound of Formula XX,

or a lactone thereof of formula XIX or XXI,

wherein said pharmaceutical composition comprises at least 5 wt % of the compound of Formula XX, XIX or XXI, and wherein said compound of Formula XX, XIX or XXI is the sole antimicrobial agent in said pharmaceutical composition.

2. The method according to claim 1 , wherein the compound is of Formula XIX or Formula XX.

3. The method according to claim 1 , wherein the bacterial infection is a urogenital infection.

4. The method according to claim 1 , wherein the bacterial infection is a vaginal infection.

5. The method according to claim 1 , wherein the bacterial infection is bacterial vaginosis.

6. The method according to claim 1 , wherein the bacterial infection is selected from the group consisting of:

a. dermatitis and/or eczema;

b. a secondary infection of dermatitis or eczema;

c. acne or acneiform conditions;

d. furunculosis;

e. carbunculosis;

f. folliculitis;

g. impetigo;

h. erysipelas;

i. periodontitis;

j. a secondary infection to colonization of group A or B streptococci multiresistant bacteria;

k. perianal streptococcal dermatitis;

l. intertriginous dermatitis;

m. paronychia;

n. an infection of infected skin wounds;

o. a secondary infection to ingrown toenails or blisters of the feet;

p. an infection is associated with diabetic foot wounds;

q. a secondary infection arising after animal bite;

r. a secondary infection arising after insect bites, mosquito bites, tic bites, erythema migrans or lymphadenosis benigna cutis;

s. a secondary infection of herpes simplex;

t. a secondary infection of herpes zoster or varicella zoster;

u. blepharitis;

v. conjunctivitis;

w. vaginitis; and

x. cervicitis.

7. The method according to claim 1 , wherein the individual is a mammal.

8. The method according to claim 7 , wherein the mammal is a human.

9. The method according to claim 8 , wherein the human is a woman.

10. The method according to claim 9 , wherein the woman is pregnant.

11. The method according to claim 1 , wherein the bacterial infection is an infection of the face, scalp, torso, groin, infected skin wounds and/or feet.

12. The method according to claim 1 , wherein the compound is glucono-δ-lactone (Formula XIX)

13. The method according to claim 1 , wherein the method is for treatment and/or prevention of bacterial vaginosis and the compound is glucono-δ-lactone (Formula XIX),

14. The method according to claim 1 , wherein the pharmaceutical composition comprises no more than 10 wt % water.

15. The method according to claim 1 , wherein said pharmaceutical composition is formulated

as a tampon, vagitorium, vaginal aerosol, vaginal cup, vaginal gel, vaginal insert, vaginal patch, vaginal ring, vaginal sponge, vaginal suppository, vaginal cream, vaginal emulsion, vaginal foam, vaginal lotion, vaginal ointment, vaginal powder, vaginal shampoo, vaginal solution, vaginal spray, vaginal suspension, vaginal tablet, vaginal rod, vaginal disc, vaginal device, and any combination thereof, or wherein the pharmaceutical composition is present on a sanitary article.