Improved Delivery Systems for Moieties Including CBD Enhanced Combinations, Formulations and Chimeras

1 . A complex for use with an enhanced delivery vehicle, which comprises:

CBD derived from Hemp Oil or otherwise, and synthetics identical with the same;

and at least one hydrogel that comprises one or more of polyethylene oxide) (PEO), poly(propylene oxide) (PPO), poly(lactide-co-glycolic acid) (PLGA), poly(N-isopropylacrylamide) (PNIPAM), poly(propylene fumarate) (PPF), poly(caprolactone) (PCL), poly(urethane) (PU), poly(organophosphazene) (POP), the block polymer PEO-PPO-PEO, and ethylene vinylacetate,

an adhesive comprising a cycloalphatic hydrocarbon resin,

an acrylic adhesive with non-functionality,

and at least one additional moiety functioning as an active from the group consisting essentially of sildenafil; melatonin; vitamins B 1 , D 3 , B 12 and capsaicin/capsicum and related salts; Dihydromyricetrim; and LIDOCAINE®.

2 . The Complex of claim 1 , which further comprises at least one of:

(a) An acrylic adhesive with non-functionality and an adhesive with only OH-functionality, further comprising one of more of enhancers selected from azone, oleic acid, and dimethylsulfoxide (DMSO);

(b) A polyisobutylene (PIB adhesive) with tackifiers that improve adhesion to skin using acrylic pressure sensitive adhesive mixed in at 1-50%, optionally with a cycloaliphatic hydrocarbon resin;

(c) PIB adhesive with enhancers: at 3% of Azon or oleic acid double the transdermal delivery from PIB. The disclosure provides a graph showing transdermal flux;

(d) Hemp oil with CBD of concentration 80-95% containing at least one terpene;

(e) A semisolid hydrogel that is saturated with cannabidiol (CBD) and tetrahydrocannabinol (THC);

(f) A semisolid hydrogel comprising an oil that consists essentially of CBD and THC (80-95%, wt/vol), in combination with ethanol/water (80/20, vol/vol), optionally with one or more enhancers selected from azone, oleic acid, and limonene;

(g) A semisolid hydrogel saturated with CBD and THC oils (80-95%, wt/vol), wherein the oil is mixed with EtOH /water (80/20, vol/vol), optionally with one or more enhancers selected from azone, oleic acid, and limonene; or

(h) A THC oil of THC (80-95%) mixed with 1-20% EtOH/water or with 1-10% EtOH/water (80/20, vol/vol) wherein including greater than 10% of ethanol is capable of lowering flux of THC delivery as determinable with a reservoir patch.

3 . A sublingual pill comprising a complex of claim 2 ,

wherein additionally said pill comprises a hardness value, and a disintegration value allowing passage of the active ingredient into a subject.

4 . A transdermal patch comprising a complex of claim 2 .

5 . The transdermal patch, of claim 4 , further comprising a plurality of microneedles.

6 . A method for applying the sublingual pill of claim 3 to the buccal mucosa of a subject, and allowing a cannabinoid to transit from the patch into an oral mucosa of the subject.

7 . A method for applying the transdermal patch of claim 5 to skin of a subject, and allowing a cannabinoid to transit from the buccal patch into the skin of the subject.

8 . A method for manufacturing the device with a complex of claim 4 , comprising; the steps of;

combining the same with THC, a film, an adhesive, and a backing, to generate an uncut patch, further comprising the uncut patch to produce a cut patch that is capable of applying to skin.

9 . The method of claim 8 , further comprising a database of information governed by artificial intelligence (AI) made-up of all information and data generated by the method.

10 . Apparatus, embodying machines to manufacture patches and pills according to the Method of claim 8 with AI.

11 . The complex of claim 1 , effectively compounded with other ingredients to be safely edible.

12 . The complex of claim 1 , effectively compounded with other ingredients to be safely potable.

13 . The complex of claim 1 , compounded with effective and safe ingredients to be injected or inhaled.

14 . The complex of claim 1 , further comprising one or more of vitamin C, salicylic acid, and terpenes.

15 . The complex of claim 1 that does not include any cyclodextrin.

16 . The complex of claim 1 , wherein the at least one hydrogel is cross-linked with a cyclodextrin, and wherein the cyclodextrin comprises a beta-cyclodextrin such as hydroxypropyl-beta-cyclodextrin, sulfobutylether-beta-cyclodextrin, maltoxyl-beta-cyclodextrin, methylated cyclodextrin, alpha-cyclodextrin (6 glucopyranose units), beta-cyclodextrin (7 glucopyranose units), and gamma-cyclodextrin (8 glucopyranose units).

17 . The complex of claim 1 , wherein the at least one hydrogel is cross-linked with a cyclodextrin, and wherein the cyclodextrin consists of a beta-cyclodextrin such as hydroxypropyl-beta-cyclodextrin, sulfobutylether-beta-cyclodextrin, maltoxyl-beta-cyclodextrin, methylated cyclodextrin, alpha-cyclodextrin (6 glucopyranose units), beta-cyclodextrin (7 glucopyranose units), and gamma-cyclodextrin (8 glucopyranose units).