Method for preparing octacalcium phosphate and octacalcium phosphate prepared thereby
The present invention relates to a method of quickly preparing a large amount of octacalcium phosphate and octacalcium phosphate prepared thereby. A method of preparing octacalcium phosphate according to an embodiment of the present invention includes preparing a calcium phosphate solution, controlling an initial pH by controlling a pH of the calcium phosphate solution to a range from 5 to 6 using an acidic solution at a time point at which the pH of the calcium phosphate solution increases, heating the calcium phosphate solution to a temperature ranging from 60° C. to 90° C., and controlling a terminal pH by controlling the pH of the calcium phosphate solution to a range from 5 to 6 using a basic solution at a time point at which the pH of the heated calcium phosphate solution decreases.
1. A method of preparing octacalcium phosphate, comprising:
preparing a calcium phosphate solution;
controlling an initial pH by controlling a pH of the calcium phosphate solution to a range from 5 to 6 using an acidic solution;
heating the calcium phosphate solution of which the initial pH is controlled to a temperature ranging from 60° C. to 90° C.;
adding a heterogeneous seed comprising at least one selected from among octacalcium phosphate and dicalcium phosphate dihydrate to the heated calcium phosphate solution;
after adding the heterogeneous seed, adjusting a terminal pH by controlling the pH of the heated calcium phosphate solution to which the heterogeneous seed is added to a range from 5 to 6.
2. The method of claim 1 , wherein the preparing of the calcium phosphate solution comprises mixing a calcium phosphate hydrate and a solvent; and
an amount of the calcium phosphate hydrate being less than 10 g but exceeding 1 g relative to 1 of the solvent.
3. The method of claim 2 , wherein the calcium phosphate hydrate comprises dicalcium phosphate dihydrate.
4. The method of claim 1 , wherein an average particle size of the heterogeneous seed that is added to the calcium phosphate solution ranges from 1 nm to 1 μm.
5. The method of claim 1 , wherein an amount of the heterogeneous seed that is added to the calcium phosphate solution ranges from 0.01 parts by weight to 0.5 parts by weight based on 100 parts by weight of the calcium phosphate solution.
6. The method of claim 1 , wherein the controlling the terminal pH is performed while a temperature of the heated calcium phosphate solution is maintained in a range from 60° C. to 90° C.
7. The method of claim 1 , wherein, in the controlling the terminal pH, the octacalcium phosphate is produced at a rate ranging from 0.5 g/ ·min to 1.5 g/ ·min.